Detailed information of TA system TA006348

Experimentally validated

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/-
• Location: 3670858..3671079
• Replicon: chromosome
• Accession: CP009789
• Organism: Escherichia coli K-12 strain ER3413

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: -
• Locus tag: ER3413_3639
• Protein ID: AIZ53339.1
• Coordinates: 3670858..3670965 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	ER3413_4669
Coordinates	3671014..3671079 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER3413_3635	3666255..3667235	-	981	AIZ53335.1	transposase DDE domain protein	-
ER3413_3636	3667336..3668907	+	1572	AIZ53336.1	cellulose production protein	-
ER3413_3637	3668904..3669095	+	192	AIZ53337.1	hypothetical protein	-
ER3413_3638	3669092..3670771	+	1680	AIZ53338.1	inner membrane protein, predicted endoglucanase, DUF3260 family	-
ER3413_3639	3670858..3670965	-	108	AIZ53339.1	toxic polypeptide, small	Toxin
-	3671014..3671079	+	66	-	-	Antitoxin
ER3413_3640	3671441..3672712	+	1272	AIZ53341.1	putative transporter	-
ER3413_3641	3672742..3673746	-	1005	AIZ53342.1	dipeptide transporter	-
ER3413_3642	3673743..3674726	-	984	AIZ53343.1	dipeptide/heme transporter	-
ER3413_3643	3674737..3675639	-	903	AIZ53344.1	dipeptide/heme transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000913 Escherichia coli str. K-12 substr. MG1655 IS/Tn TA006364 3652182..3653162 0 View NZ_AP021946 Escherichia coli strain WP2-S18-ESBL-08 IS/Tn TA033901 4322569..4323549 0.003 View NZ_AP022173 Escherichia coli strain WP7-S17-ESBL-01 IS/Tn TA034852 4478747..4479727 0.003 View NZ_AP024687 Escherichia coli strain FUJ80154 IS/Tn TA039229 4387627..4388607 0.003 View NZ_CP009644 Escherichia coli ER2796 strain K-12 ER2796 IS/Tn 3666257..3667237 0 View NZ_CP009789 Escherichia coli K-12 strain K-12 ER3413 IS/Tn 3666255..3667235 0 View NZ_CP009859 Escherichia coli strain ECONIH1 IS/Tn TA050033 5188163..5189143 0.003 View NZ_CP010438 Escherichia coli K-12 strain K-12 MG1655 IS/Tn TA052454 4430601..4431581 0 View NZ_CP010439 Escherichia coli K-12 strain K-12 MG1655 IS/Tn 4415415..4416395 0 View NZ_CP010440 Escherichia coli K-12 strain K-12 MG1655 IS/Tn TA052525 4432036..4433016 0 View NZ_CP010441 Escherichia coli K-12 strain K-12 MG1655 IS/Tn TA052566 4418506..4419486 0 View NZ_CP010442 Escherichia coli K-12 strain K-12 MG1655 IS/Tn TA052608 4471304..4472284 0 View NZ_CP010443 Escherichia coli K-12 strain K-12 MG1655 IS/Tn TA052649 4417731..4418711 0 View NZ_CP010444 Escherichia coli K-12 strain K-12 MG1655 IS/Tn TA052690 4420501..4421481 0 View NZ_CP011113 Escherichia coli strain RR1 IS/Tn TA053404 1547830..1548810 0 View NZ_CP015834 Escherichia coli strain MS6198 IS/Tn TA063625 5054397..5055377 0.003 View NZ_CP017848 Escherichia coli strain FMU073332 IS/Tn TA068214 24687..25667 0.002 View NZ_CP018982 Escherichia coli strain Ecol_867 IS/Tn TA071216 1648..2628 0.002 View NZ_CP019392 Escherichia coli strain XH992 IS/Tn TA072360 133784..134764 0.003 View NZ_CP023142 Escherichia coli strain CFSAN061770 IS/Tn TA080498 4476767..4477747 0.002 View NZ_CP024262 Escherichia coli strain F5656C1 IS/Tn 36452..37432 0.002 View NZ_CP024801 Escherichia coli strain AMA1167 IS/Tn TA088541 2342558..2343538 0.003 View NZ_CP025944 Escherichia coli strain SCEC020023 IS/Tn TA092527 29421..30401 0.003 View NZ_CP029239 Escherichia coli strain BH212 IS/Tn TA105307 4589773..4590753 0 View NZ_CP030768 Escherichia coli strain 2017C-4173W12 IS/Tn TA107900 2521033..2522013 0.003 View NZ_CP032515 Escherichia coli strain 118UI IS/Tn TA111915 5078091..5079071 0.003 View NZ_CP038456 Escherichia coli strain EC-129 IS/Tn TA122840 54557..55537 0.003 View NZ_CP040919 Escherichia coli strain FC853_EC IS/Tn TA127253 4249921..4250901 0.003 View NZ_CP041110 Escherichia coli strain ECCTRSRTH03 IS/Tn TA127617 3613510..3614490 0.003 View NZ_CP043183 Escherichia coli O16:H48 strain PG20180172 IS/Tn TA137413 3454108..3455088 0 View NZ_CP043185 Escherichia coli O16:H48 strain PG20180171 IS/Tn TA137458 3815934..3816914 0 View NZ_CP043187 Escherichia coli O16:H48 strain PG20180170 IS/Tn TA137481 3454103..3455083 0 View NZ_CP043189 Escherichia coli O16:H48 strain PG20180175 IS/Tn TA137512 3454106..3455086 0 View NZ_CP043191 Escherichia coli O16:H48 strain PG20180173 IS/Tn TA137544 3454106..3455086 0 View NZ_CP043193 Escherichia coli O16:H48 strain PG20180063 IS/Tn TA137574 3454109..3455089 0 View NZ_CP043195 Escherichia coli O16:H48 strain PG20180062 IS/Tn TA137605 3742168..3743148 0 View NZ_CP043197 Escherichia coli O16:H48 strain PG20180061 IS/Tn TA137616 777101..778081 0 View NZ_CP043199 Escherichia coli O16:H48 strain PG20180060 IS/Tn TA137659 1462834..1463814 0 View NZ_CP043201 Escherichia coli O16:H48 strain PG20180059 IS/Tn TA137714 3453925..3454905 0 View NZ_CP043203 Escherichia coli O16:H48 strain PG20180058 IS/Tn TA137747 3454106..3455086 0 View NZ_CP043205 Escherichia coli O16:H48 strain PG20180054 IS/Tn TA137780 3454106..3455086 0 View NZ_CP043207 Escherichia coli O16:H48 strain PG20180053 IS/Tn TA137813 3454106..3455086 0 View NZ_CP043209 Escherichia coli O16:H48 strain PG20180052 IS/Tn TA137846 3454106..3455086 0 View NZ_CP043211 Escherichia coli O16:H48 strain PG20180050 IS/Tn TA137879 3739081..3740061 0 View NZ_CP043213 Escherichia coli O16:H48 strain CV601gfp IS/Tn TA137900 901449..902429 0 View NZ_CP043406 Escherichia coli strain NMBU-W13E19 IS/Tn TA138692 2610317..2611297 0.003 View NZ_CP046025 Escherichia coli strain C439 IS/Tn TA143417 3455442..3456422 0 View NZ_CP051694 Escherichia coli strain SCU-313 IS/Tn TA154828 4398917..4399897 0.003 View NZ_CP053247 Escherichia coli strain SCU-482 IS/Tn TA156396 1572038..1573018 0.003 View NZ_CP053662 Escherichia coli strain eco-241 IS/Tn TA157377 4508284..4509264 0.003 View NZ_CP054665 Escherichia coli strain IGC_EcoliInv_1.1 IS/Tn TA160040 1389324..1390304 0 View NZ_CP056036 Escherichia coli strain EC31 IS/Tn TA162541 4531285..4532265 0.003 View NZ_CP058574 Escherichia coli strain EC1 IS/Tn TA166862 4356449..4357429 0.003 View NZ_CP060708 Escherichia coli strain MFDpir IS/Tn TA170774 1394318..1395298 0 View NZ_CP060988 Escherichia coli strain EC31 IS/Tn TA171915 15338..16318 0.004 View NZ_CP062815 Escherichia coli strain Res13-Sevr-PER06-05-b-A IS/Tn TA176679 2310370..2311350 0.003 View NZ_CP062820 Escherichia coli strain Res13-Sevr-PER06-05-b-A IS/Tn TA176697 98701..99681 0.003 View NZ_CP062826 Escherichia coli strain Res13-Lact-PER12-33-A IS/Tn TA176753 2310498..2311478 0.003 View NZ_CP062831 Escherichia coli strain Res13-Lact-PER12-33-A IS/Tn TA176771 98704..99684 0.003 View NZ_CP062832 Escherichia coli strain Res13-Lact-PER04-33 IS/Tn TA176789 2310527..2311507 0.003 View NZ_CP062837 Escherichia coli strain Res13-Lact-PER04-33 IS/Tn TA176807 98697..99677 0.003 View NZ_CP062838 Escherichia coli strain Res13-Lact-PER02-33 IS/Tn TA176825 2310510..2311490 0.003 View NZ_CP062843 Escherichia coli strain Res13-Lact-PER02-33 IS/Tn TA176843 98704..99684 0.003 View NZ_CP062863 Escherichia coli strain Res13-Lact-PEB14-36 IS/Tn TA176925 619208..620188 0.003 View NZ_CP062883 Escherichia coli strain Res13-Lact-PEA06-10 IS/Tn TA177127 2312416..2313396 0.003 View NZ_CP062888 Escherichia coli strain Res13-Lact-PEA06-10 IS/Tn TA177145 98696..99676 0.003 View NZ_CP062895 Escherichia coli strain Res13-Lact-ER02-39 IS/Tn TA177200 2310505..2311485 0.003 View NZ_CP062900 Escherichia coli strain Res13-Lact-ER02-39 IS/Tn TA177218 98704..99684 0.003 View NZ_CP062908 Escherichia coli strain Res13-Lact-EB12-05 IS/Tn TA177253 619208..620188 0.003 View NZ_CP063492 Escherichia coli strain EF5-18-41 IS/Tn TA178471 1313456..1314436 0.003 View NZ_CP067299 Escherichia coli strain ABW_A33 IS/Tn TA186000 508414..509394 0.003 View NZ_CP067303 Escherichia coli strain ABW_A32 IS/Tn TA186032 508414..509394 0.003 View NZ_CP067994 Escherichia coli strain CV601 IS/Tn TA186404 3454959..3455939 0 View NZ_CP068806 Escherichia coli strain RIVM_C018576 IS/Tn TA187998 493364..494344 0.003 View NZ_CP068825 Escherichia coli strain RIVM_C030256 IS/Tn TA188607 493364..494344 0.003 View NZ_CP069980 Escherichia coli strain FDAARGOS_1291 IS/Tn TA192469 2632191..2633171 0.003 View NZ_CP070007 Escherichia coli strain FDAARGOS_1288 IS/Tn TA192623 1111180..1112160 0.003 View NZ_CP070048 Escherichia coli strain FDAARGOS_1290 IS/Tn TA192849 4382788..4383768 0.003 View NZ_CP071073 Escherichia coli strain 3347558 IS/Tn TA195199 533148..534128 0.003 View NZ_CP072986 Escherichia coli strain T159A IS/Tn TA199416 3455442..3456422 0 View NZ_CP074001 Escherichia coli strain PM4 IS/Tn TA201021 2324453..2325433 0.002 View NZ_CP074359 Escherichia coli strain XJ6.2 IS/Tn TA201945 3952984..3953964 0.003 View NZ_CP074680 Escherichia coli strain MEI008 IS/Tn TA202641 4175691..4176671 0.003 View NZ_CP076043 Escherichia coli strain Stbl4 IS/Tn 1548755..1549735 0 View NZ_CP081888 Escherichia coli strain WW2 IS/Tn TA213635 7658..8638 0.001 View NZ_CP082827 Escherichia coli strain SCAID WND2-2021 (3/145) IS/Tn TA215294 4436535..4437515 0.003 View NZ_CP086678 Escherichia coli strain EFF60 IS/Tn TA224364 4459347..4460327 0.002 View NZ_CP095083 Escherichia coli strain EC6868 IS/Tn TA241231 4534822..4535802 0.003 View NZ_CP095155 Escherichia coli strain Iso00041 IS/Tn TA241586 4266211..4267191 0.003 View NZ_CP095448 Escherichia coli strain LS45 IS/Tn TA242032 4327154..4328134 0.003 View NZ_CP095510 Escherichia coli strain GN02270 IS/Tn TA242127 4702389..4703369 0.003 View NZ_CP095526 Escherichia coli strain GN05505 IS/Tn TA242269 3472505..3473485 0.003 View NZ_CP095538 Escherichia coli strain GN04592 IS/Tn TA242376 4147603..4148583 0.003 View NZ_CP097716 Escherichia coli strain MS1718 IS/Tn TA246106 4391451..4392431 0.003 View NZ_CP098197 Escherichia coli strain Z0117EC0062 IS/Tn TA246985 4333827..4334807 0.003 View NZ_CP104665 Escherichia coli strain 2021CK-00607 IS/Tn TA258932 4378636..4379616 0.003 View NZ_CP109874 Escherichia coli strain EC488 IS/Tn TA262261 4346451..4347431 0.003 View NZ_CP116900 Escherichia coli strain XH2172 IS/Tn TA269326 3761256..3762236 0.003 View NZ_CP117010 Escherichia coli strain MLI110 IS/Tn TA269792 1100798..1101778 0.003 View NZ_CP117049 Escherichia coli strain MLI106K2 IS/Tn TA269941 4280411..4281391 0.003 View NZ_CP117053 Escherichia coli strain MLI106K4 IS/Tn TA269974 4280411..4281391 0.003 View NZ_CP122844 Escherichia coli strain ETEC1722 IS/Tn TA278062 2395467..2396447 0.002 View NZ_CP122859 Escherichia coli strain ETEC1720 IS/Tn TA278091 2398468..2399448 0.002 View NZ_LR130564 Escherichia coli strain MS14387 isolate MS14387 IS/Tn TA286497 4421709..4422689 0.003 View NZ_LR881938 Escherichia coli str. K-12 substr. MG1655 strain K-12 IS/Tn TA289509 1394137..1395117 0 View NZ_LR890288 Escherichia coli isolate MSB1_1A-sc-2280383 IS/Tn TA290513 4125983..4126963 0.003 View NZ_LR890405 Escherichia coli isolate MSB1_7C-sc-2280317 IS/Tn TA290904 4435262..4436242 0.003 View NZ_LR890603 Escherichia coli isolate MSB1_8G-sc-2280388 IS/Tn TA291532 4128757..4129737 0.003 View NC_000913 Escherichia coli str. K-12 substr. MG1655 IS/Tn TA006364 3652182..3653162 0	flank	IS/Tn	-	-	3666255..3667235	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T6348 AIZ53339.1 CP009789:c3670965-3670858 [Escherichia coli K-12]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T6348 CP009789:c3670965-3670858 [Escherichia coli K-12]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT6348 CP009789:3671014-3671079 [Escherichia coli K-12]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
T6344	Escherichia coli str. K-12 substr. W3110	100	100	1
T6332	Escherichia coli str. K-12 substr. MG1655	100	100	1
T6336	Escherichia coli str. K-12 substr. DH10B	100	100	1
T6328	Escherichia coli str. K-12 substr. MC4100	100	100	1
T6340	Escherichia coli str. K-12 substr. MDS42	100	100	1
T6339	Escherichia coli str. K-12 substr. MDS42	57.143	100	0.571
T6346	Escherichia coli K-12 strain ER3413	57.143	100	0.571
T6345	Escherichia coli K-12 strain ER3413	57.143	100	0.571
T6347	Escherichia coli K-12 strain ER3413	57.143	100	0.571
T6326	Escherichia coli str. K-12 substr. MC4100	57.143	100	0.571
T6338	Escherichia coli str. K-12 substr. MDS42	57.143	100	0.571
T6334	Escherichia coli str. K-12 substr. DH10B	57.143	100	0.571
T6342	Escherichia coli str. K-12 substr. W3110	57.143	100	0.571
T6330	Escherichia coli str. K-12 substr. MG1655	57.143	100	0.571
T6327	Escherichia coli str. K-12 substr. MC4100	57.143	100	0.571
T6325	Escherichia coli str. K-12 substr. MC4100	57.143	100	0.571
T6337	Escherichia coli str. K-12 substr. MDS42	57.143	100	0.571
T6335	Escherichia coli str. K-12 substr. DH10B	57.143	100	0.571
T6333	Escherichia coli str. K-12 substr. DH10B	57.143	100	0.571
T6343	Escherichia coli str. K-12 substr. W3110	57.143	100	0.571
T6341	Escherichia coli str. K-12 substr. W3110	57.143	100	0.571
T6329	Escherichia coli str. K-12 substr. MG1655	57.143	100	0.571
T6331	Escherichia coli str. K-12 substr. MG1655	57.143	100	0.571

Multiple sequence alignment

Structures

Antitoxin

References

(1) Mitsuoki Kawano et al. (2002) Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Molecular Microbiology 45(2):333-49. [PubMed:12123448]


 experimental literature