186000

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 505435..506249 Replicon chromosome
Accession NZ_CP067299
Organism Escherichia coli strain ABW_A33

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JJB24_RS02400 Protein ID WP_001054376.1
Coordinates 505992..506249 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JJB24_RS02395 Protein ID WP_001309181.1
Coordinates 505435..505980 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB24_RS02365 (501126) 501126..502439 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
JJB24_RS02370 (502451) 502451..502729 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
JJB24_RS02375 (502726) 502726..503847 - 1122 WP_000010829.1 M42 family metallopeptidase -
JJB24_RS02380 (504092) 504092..504208 - 117 Protein_468 VOC family protein -
JJB24_RS02385 (504246) 504246..504464 - 219 Protein_469 hypothetical protein -
JJB24_RS02390 (504633) 504633..505379 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JJB24_RS02395 (505435) 505435..505980 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
JJB24_RS02400 (505992) 505992..506249 - 258 WP_001054376.1 YjhX family toxin Toxin
JJB24_RS23755 (506740) 506740..506871 - 132 WP_001309182.1 hypothetical protein -
JJB24_RS02410 (506987) 506987..508227 + 1241 Protein_474 helicase YjhR -
JJB24_RS02415 (508414) 508414..509394 + 981 WP_000019400.1 IS5-like element IS5 family transposase -
JJB24_RS23760 (509694) 509694..509899 - 206 Protein_476 HNH endonuclease -
JJB24_RS02420 (510009) 510009..510989 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 505435..518424 12989
flank IS/Tn - - 508414..509394 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T186000 WP_001054376.1 NZ_CP067299:c506249-505992 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T186000 NZ_CP089142:1050423-1050758 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT186000 WP_001309181.1 NZ_CP067299:c505980-505435 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT186000 NZ_CP089142:1050175-1050423 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References