27426

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4513009..4513823 Replicon chromosome
Accession NC_017638
Organism Escherichia coli DH1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ECDH1ME8569_RS22230 Protein ID WP_001054376.1
Coordinates 4513566..4513823 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ECDH1ME8569_RS22225 Protein ID WP_001309181.1
Coordinates 4513009..4513554 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECDH1ME8569_RS22205 (ECDH1ME8569_4161) 4508700..4510013 - 1314 WP_000460842.1 galactitol-specific PTS transporter subunit IIC -
ECDH1ME8569_RS22210 (ECDH1ME8569_4162) 4510025..4510303 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECDH1ME8569_RS22215 (ECDH1ME8569_4163) 4510300..4511421 - 1122 WP_000010829.1 M42 family metallopeptidase -
ECDH1ME8569_RS25315 4511666..4511782 - 117 Protein_4214 VOC family protein -
ECDH1ME8569_RS24655 4511820..4512038 - 219 Protein_4215 hypothetical protein -
ECDH1ME8569_RS22220 (ECDH1ME8569_4164) 4512207..4512953 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ECDH1ME8569_RS22225 (ECDH1ME8569_4165) 4513009..4513554 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
ECDH1ME8569_RS22230 (ECDH1ME8569_4166) 4513566..4513823 - 258 WP_001054376.1 hypothetical protein Toxin
ECDH1ME8569_RS25125 4514200..4514445 - 246 Protein_4219 GNAT family N-acetyltransferase -
ECDH1ME8569_RS22245 (ECDH1ME8569_4167) 4514561..4515801 + 1241 Protein_4220 helicase YjhR -
ECDH1ME8569_RS22250 (ECDH1ME8569_4168) 4516384..4517364 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECDH1ME8569_RS22255 (ECDH1ME8569_4169) 4517429..4518535 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4513009..4524807 11798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T27426 WP_001054376.1 NC_017638:c4513823-4513566 [Escherichia coli DH1]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T27426 NC_017638:c4513823-4513566 [Escherichia coli DH1]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT27426 WP_001309181.1 NC_017638:c4513554-4513009 [Escherichia coli DH1]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT27426 NC_017638:c4513554-4513009 [Escherichia coli DH1]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References