Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4522868..4523682 Replicon chromosome
Accession NZ_CP069935
Organism Escherichia coli strain FDAARGOS_1302

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag I6K32_RS21930 Protein ID WP_001054376.1
Coordinates 4523425..4523682 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag I6K32_RS21925 Protein ID WP_001350781.1
Coordinates 4522868..4523413 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K32_RS21895 (4518559) 4518559..4519872 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
I6K32_RS21900 (4519884) 4519884..4520162 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
I6K32_RS21905 (4520159) 4520159..4521280 - 1122 WP_000010829.1 M42 family metallopeptidase -
I6K32_RS21910 (4521525) 4521525..4521641 - 117 Protein_4318 VOC family protein -
I6K32_RS21915 (4521679) 4521679..4521897 - 219 Protein_4319 hypothetical protein -
I6K32_RS21920 (4522066) 4522066..4522812 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
I6K32_RS21925 (4522868) 4522868..4523413 - 546 WP_001350781.1 N-acetyltransferase Antitoxin
I6K32_RS21930 (4523425) 4523425..4523682 - 258 WP_001054376.1 YjhX family toxin Toxin
I6K32_RS25225 (4524173) 4524173..4524304 - 132 WP_001309182.1 hypothetical protein -
I6K32_RS21940 (4524420) 4524420..4525660 + 1241 Protein_4324 helicase YjhR -
I6K32_RS25230 (4525928) 4525928..4526133 - 206 Protein_4325 HNH endonuclease -
I6K32_RS21945 (4526243) 4526243..4527223 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
I6K32_RS21950 (4527288) 4527288..4528394 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4522868..4534659 11791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T192161 WP_001054376.1 NZ_CP069935:c4523682-4523425 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T192161 NZ_CP092107:c1694632-1694129 [Vibrio sp. JC009]
ATGATGAATTCGGTACTTCTGGACAAATCGAAACACAACAGAAATAGATTCAATTGTGGCATTGAAGCCCTCAATAACTA
TCTAAAAGTAATGGCTAATCAGCAAGCCAAGAAAGACAACACCAGAACTTTTGTTCTGGAAGACGAAAATGATAATTCGT
ATATCATCGGCTTTTATACATTGACGATGACACCAATTAACTTGGAGGCTTTGCCCGATAAGTTACAGAAAAAGCACCAA
TCATCAACTTCCGGAGGTCTCATTGCTCGCTTGGCTATTGATGAGCGCTACAAAGGAAAAGGATTTGGCGAATGGTTGCT
TATTGATGCTCTACGAAAATTATTGACCGCTAGTGACAGCGTGGCATTCCCTGTTGTAATTGTTGATGCCAAAGATGGAG
CAAAACAGTTCTACGAGCGCTATGGATTTCAGGCATTTCAAAGTGCAGAAAACAAATTGTTCATCACGATTTCTGATGTC
AGAGAGAGCTTGGAGTATCAGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT192161 WP_001350781.1 NZ_CP069935:c4523413-4522868 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT192161 NZ_CP092107:c1694901-1694629 [Vibrio sp. JC009]
ATGGCAGCTACATTGCCTCGCATCACCGCCAGGGTTGATGTCGATACACAAGATTTACTTACTAAAGCTGCTGCGATTGC
AGGTATGTCTAGTATTAATTCATTTGTTCTAAGTGCTGCAATTGAGAAAGCAAAAGAGGTTATCGAACGTGAACAAGCTC
TAAGGCTTAGTCAAAAGGATGCATTGTTGCTTATGGAAGCGCTTGACCGACCTGCAAAACCAAACGCAAAATTGAAAGCT
GCAGCTAAACGTTATGAGCACAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References