285034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4419085..4419899 Replicon chromosome
Accession NZ_HG738867
Organism Escherichia coli str. K-12 substr. MC4100 strain K-12

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag BN896_RS21855 Protein ID WP_001054376.1
Coordinates 4419642..4419899 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag BN896_RS21850 Protein ID WP_001309181.1
Coordinates 4419085..4419630 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN896_RS21830 (BN896_4001) 4414776..4416089 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
BN896_RS21835 (BN896_4002) 4416101..4416379 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
BN896_RS21840 (BN896_4003) 4416376..4417497 - 1122 WP_000010829.1 M42 family metallopeptidase -
BN896_RS25480 4417742..4417858 - 117 Protein_4126 VOC family protein -
BN896_RS24895 4417896..4418114 - 219 Protein_4127 hypothetical protein -
BN896_RS21845 (BN896_4004) 4418283..4419029 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
BN896_RS21850 (BN896_4005) 4419085..4419630 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
BN896_RS21855 (BN896_4006) 4419642..4419899 - 258 WP_001054376.1 hypothetical protein Toxin
BN896_RS25330 4420276..4420521 - 246 Protein_4131 GNAT family N-acetyltransferase -
BN896_RS21870 4420637..4421877 + 1241 Protein_4132 helicase YjhR -
BN896_RS21875 (BN896_4007) 4422460..4423440 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
BN896_RS21880 (BN896_4008) 4423505..4424611 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimE / fimA / fimI / fimC 4419085..4430625 11540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T285034 WP_001054376.1 NZ_HG738867:c4419899-4419642 [Escherichia coli str. K-12 substr. MC4100]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T285034 NZ_HG738867:c4419899-4419642 [Escherichia coli str. K-12 substr. MC4100]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT285034 WP_001309181.1 NZ_HG738867:c4419630-4419085 [Escherichia coli str. K-12 substr. MC4100]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT285034 NZ_HG738867:c4419630-4419085 [Escherichia coli str. K-12 substr. MC4100]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References