52489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 652082..652896 Replicon chromosome
Accession NZ_CP010440
Organism Escherichia coli K-12 strain K-12 MG1655

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag SH08_RS03175 Protein ID WP_001054376.1
Coordinates 652639..652896 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag SH08_RS03170 Protein ID WP_001309181.1
Coordinates 652082..652627 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SH08_RS03150 647773..649086 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
SH08_RS03155 649098..649376 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
SH08_RS03160 649373..650494 - 1122 WP_000010829.1 M42 family metallopeptidase -
SH08_RS26025 650739..650855 - 117 Protein_573 VOC family protein -
SH08_RS24990 650893..651111 - 219 Protein_574 hypothetical protein -
SH08_RS03165 651280..652026 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
SH08_RS03170 652082..652627 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
SH08_RS03175 652639..652896 - 258 WP_001054376.1 hypothetical protein Toxin
SH08_RS25510 653273..653518 - 246 Protein_578 GNAT family N-acetyltransferase -
SH08_RS03190 653634..654874 + 1241 Protein_579 helicase YjhR -
SH08_RS03195 655457..656437 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
SH08_RS03200 656502..657608 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 652082..663872 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T52489 WP_001054376.1 NZ_CP010440:c652896-652639 [Escherichia coli K-12]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T52489 NZ_CP010440:c652896-652639 [Escherichia coli K-12]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT52489 WP_001309181.1 NZ_CP010440:c652627-652082 [Escherichia coli K-12]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT52489 NZ_CP010440:c652627-652082 [Escherichia coli K-12]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References