68445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4432698..4433512 Replicon chromosome
Accession NZ_CP017979
Organism Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag BL257_RS23465 Protein ID WP_001054376.1
Coordinates 4433255..4433512 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag BL257_RS23460 Protein ID WP_001309181.1
Coordinates 4432698..4433243 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL257_RS23435 (BL257_21930) 4428389..4429702 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
BL257_RS23440 (BL257_21935) 4429714..4429992 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
BL257_RS23445 (BL257_21940) 4429989..4431110 - 1122 WP_000010829.1 M42 family metallopeptidase -
BL257_RS25200 4431355..4431471 - 117 Protein_4192 VOC family protein -
BL257_RS24515 4431509..4431727 - 219 Protein_4193 hypothetical protein -
BL257_RS23455 (BL257_21945) 4431896..4432642 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
BL257_RS23460 (BL257_21950) 4432698..4433243 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
BL257_RS23465 (BL257_21955) 4433255..4433512 - 258 WP_001054376.1 hypothetical protein Toxin
BL257_RS24995 4433889..4434134 - 246 Protein_4197 GNAT family N-acetyltransferase -
BL257_RS23480 (BL257_21970) 4434250..4435490 + 1241 Protein_4198 helicase YjhR -
BL257_RS23490 (BL257_21975) 4436073..4437053 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
BL257_RS23495 (BL257_21980) 4437118..4438224 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4432698..4444488 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T68445 WP_001054376.1 NZ_CP017979:c4433512-4433255 [Escherichia coli str. K-12 substr. W3110]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T68445 NZ_CP017979:c4433512-4433255 [Escherichia coli str. K-12 substr. W3110]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT68445 WP_001309181.1 NZ_CP017979:c4433243-4432698 [Escherichia coli str. K-12 substr. W3110]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT68445 NZ_CP017979:c4433243-4432698 [Escherichia coli str. K-12 substr. W3110]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References