293359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4529713..4530527 Replicon chromosome
Accession NZ_LT615377
Organism Escherichia coli isolate 106

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag BV315_RS23950 Protein ID WP_001054376.1
Coordinates 4530270..4530527 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag BV315_RS23945 Protein ID WP_001309181.1
Coordinates 4529713..4530258 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV315_RS23920 4525404..4526717 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
BV315_RS23925 4526729..4527007 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
BV315_RS23930 4527004..4528125 - 1122 WP_000010829.1 M42 family metallopeptidase -
BV315_RS25505 4528370..4528486 - 117 Protein_4265 VOC family protein -
BV315_RS24870 4528524..4528742 - 219 Protein_4266 hypothetical protein -
BV315_RS23940 4528911..4529657 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
BV315_RS23945 4529713..4530258 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
BV315_RS23950 4530270..4530527 - 258 WP_001054376.1 hypothetical protein Toxin
BV315_RS25345 4530904..4531149 - 246 Protein_4270 GNAT family N-acetyltransferase -
BV315_RS23960 4531265..4532505 + 1241 Protein_4271 helicase YjhR -
BV315_RS23970 4533088..4534068 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
BV315_RS23975 4534133..4535239 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4529713..4541503 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T293359 WP_001054376.1 NZ_LT615377:c4530527-4530270 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT293359 WP_001309181.1 NZ_LT615377:c4530258-4529713 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References