21460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4537919..4538733 Replicon chromosome
Accession NC_007779
Organism Escherichia coli str. K-12 substr. W3110

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag Y75_RS22480 Protein ID WP_001054376.1
Coordinates 4538476..4538733 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag Y75_RS22475 Protein ID WP_001309181.1
Coordinates 4537919..4538464 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y75_RS22455 (Y75_p4188) 4533610..4534923 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
Y75_RS22460 (Y75_p4189) 4534935..4535213 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
Y75_RS22465 (Y75_p4190) 4535210..4536331 - 1122 WP_000010829.1 M42 family metallopeptidase -
Y75_RS25195 4536576..4536692 - 117 Protein_4253 VOC family protein -
Y75_RS24655 4536730..4536948 - 219 Protein_4254 hypothetical protein -
Y75_RS22470 (Y75_p4191) 4537117..4537863 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
Y75_RS22475 (Y75_p4192) 4537919..4538464 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
Y75_RS22480 (Y75_p4193) 4538476..4538733 - 258 WP_001054376.1 hypothetical protein Toxin
Y75_RS25090 4539110..4539355 - 246 Protein_4258 GNAT family N-acetyltransferase -
Y75_RS22495 (Y75_p4194) 4539471..4540711 + 1241 Protein_4259 helicase YjhR -
Y75_RS22500 (Y75_p4195) 4541294..4542274 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
Y75_RS22505 (Y75_p4196) 4542339..4543445 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4537919..4549709 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T21460 WP_001054376.1 NC_007779:c4538733-4538476 [Escherichia coli str. K-12 substr. W3110]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T21460 NC_007779:c4538733-4538476 [Escherichia coli str. K-12 substr. W3110]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT21460 WP_001309181.1 NC_007779:c4538464-4537919 [Escherichia coli str. K-12 substr. W3110]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT21460 NC_007779:c4538464-4537919 [Escherichia coli str. K-12 substr. W3110]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References