34376

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4459049..4459863 Replicon chromosome
Accession NZ_AP022069
Organism Escherichia coli strain WP4-W18-ESBL-09

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag H7R28_RS21255 Protein ID WP_001054376.1
Coordinates 4459049..4459306 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag H7R28_RS21260 Protein ID WP_001309181.1
Coordinates 4459318..4459863 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R28_RS21235 4454337..4455443 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
H7R28_RS21240 4455508..4456488 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
H7R28_RS21245 4457071..4458311 - 1241 Protein_4154 DNA helicase -
H7R28_RS21250 4458427..4458672 + 246 Protein_4155 GNAT family N-acetyltransferase -
H7R28_RS21255 4459049..4459306 + 258 WP_001054376.1 hypothetical protein Toxin
H7R28_RS21260 4459318..4459863 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
H7R28_RS21265 4459919..4460665 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
H7R28_RS21270 4460834..4461052 + 219 Protein_4159 hypothetical protein -
H7R28_RS27020 4461090..4461206 + 117 Protein_4160 VOC family protein -
H7R28_RS21275 4461451..4462572 + 1122 WP_000010829.1 M42 family metallopeptidase -
H7R28_RS21280 4462569..4462847 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
H7R28_RS21285 4462859..4464172 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB 4451543..4459863 8320


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T34376 WP_001054376.1 NZ_AP022069:4459049-4459306 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T34376 NZ_AP022069:4459049-4459306 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT34376 WP_001309181.1 NZ_AP022069:4459318-4459863 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT34376 NZ_AP022069:4459318-4459863 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References