48705

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4523056..4523870 Replicon chromosome
Accession NZ_CP009273
Organism Escherichia coli BW25113

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag BW25113_RS22385 Protein ID WP_001054376.1
Coordinates 4523613..4523870 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag BW25113_RS22380 Protein ID WP_001309181.1
Coordinates 4523056..4523601 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW25113_RS22360 (BW25113_4304) 4518747..4520060 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
BW25113_RS22365 (BW25113_4565) 4520072..4520350 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
BW25113_RS22370 (BW25113_4305) 4520347..4521468 - 1122 WP_000010829.1 M42 family metallopeptidase -
BW25113_RS26025 4521713..4521829 - 117 Protein_4238 VOC family protein -
BW25113_RS25375 (BW25113_4656) 4521867..4522085 - 219 Protein_4239 hypothetical protein -
BW25113_RS22375 (BW25113_4306) 4522254..4523000 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
BW25113_RS22380 (BW25113_4307) 4523056..4523601 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
BW25113_RS22385 (BW25113_4566) 4523613..4523870 - 258 WP_001054376.1 hypothetical protein Toxin
BW25113_RS25835 (BW25113_4657) 4524247..4524492 - 246 Protein_4243 GNAT family N-acetyltransferase -
BW25113_RS22400 (BW25113_4308) 4524608..4525848 + 1241 Protein_4244 helicase YjhR -
BW25113_RS22405 (BW25113_4309) 4526431..4527411 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
BW25113_RS22410 (BW25113_4310) 4527476..4528582 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4523056..4534846 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T48705 WP_001054376.1 NZ_CP009273:c4523870-4523613 [Escherichia coli BW25113]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T48705 NZ_CP009273:c4523870-4523613 [Escherichia coli BW25113]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT48705 WP_001309181.1 NZ_CP009273:c4523601-4523056 [Escherichia coli BW25113]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT48705 NZ_CP009273:c4523601-4523056 [Escherichia coli BW25113]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References