151708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 575343..576157 Replicon chromosome
Accession NZ_CP049852
Organism Escherichia coli strain UPEC-774U/190308

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag G9W34_RS02765 Protein ID WP_001054376.1
Coordinates 575900..576157 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag G9W34_RS02760 Protein ID WP_001540600.1
Coordinates 575343..575888 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W34_RS02730 (571034) 571034..572347 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
G9W34_RS02735 (572359) 572359..572637 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
G9W34_RS02740 (572634) 572634..573755 - 1122 WP_000010829.1 M42 family metallopeptidase -
G9W34_RS02745 (574000) 574000..574116 - 117 Protein_533 VOC family protein -
G9W34_RS02750 (574154) 574154..574372 - 219 Protein_534 hypothetical protein -
G9W34_RS02755 (574541) 574541..575287 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
G9W34_RS02760 (575343) 575343..575888 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
G9W34_RS02765 (575900) 575900..576157 - 258 WP_001054376.1 YjhX family toxin Toxin
G9W34_RS24870 (576648) 576648..576779 - 132 WP_001309182.1 hypothetical protein -
G9W34_RS02775 (576895) 576895..578135 + 1241 Protein_539 helicase YjhR -
G9W34_RS24875 (578403) 578403..578608 - 206 Protein_540 HNH endonuclease -
G9W34_RS02780 (578718) 578718..579698 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
G9W34_RS02785 (579763) 579763..580869 - 1107 WP_219934327.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 575343..587133 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T151708 WP_001054376.1 NZ_CP049852:c576157-575900 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T151708 NZ_CP065673:c4887519-4887337 [Serratia plymuthica]
GTGAAAAGTTCAGAACTGATCAGGCTGTTAGAACGAGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACACCCGGGATCTCGTTTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAGATCA
TGAAAGATGCCGGGCTGTGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT151708 WP_001540600.1 NZ_CP049852:c575888-575343 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT151708 NZ_CP065673:c4887307-4886894 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACCTCGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGATACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGATGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATTCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACACCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATCAATATCACTCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGTAATGAATTAT
TGAAAGTCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References