23876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4469997..4470811 Replicon chromosome
Accession NC_012759
Organism Escherichia coli BW2952

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag BWG_RS22215 Protein ID WP_001054376.1
Coordinates 4470554..4470811 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag BWG_RS22210 Protein ID WP_001309181.1
Coordinates 4469997..4470542 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWG_RS22190 (BWG_4001) 4465688..4467001 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
BWG_RS22195 (BWG_4002) 4467013..4467291 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
BWG_RS22200 (BWG_4003) 4467288..4468409 - 1122 WP_000010829.1 M42 family metallopeptidase -
BWG_RS25965 4468654..4468770 - 117 Protein_4209 VOC family protein -
BWG_RS25305 4468808..4469026 - 219 Protein_4210 hypothetical protein -
BWG_RS22205 (BWG_4004) 4469195..4469941 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
BWG_RS22210 (BWG_4005) 4469997..4470542 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
BWG_RS22215 (BWG_4006) 4470554..4470811 - 258 WP_001054376.1 hypothetical protein Toxin
BWG_RS25765 4471188..4471433 - 246 Protein_4214 GNAT family N-acetyltransferase -
BWG_RS22230 4471549..4472789 + 1241 Protein_4215 helicase YjhR -
BWG_RS22235 (BWG_4007) 4473372..4474352 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
BWG_RS22240 (BWG_4008) 4474417..4475523 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimE / fimA / fimI / fimC 4469997..4481537 11540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T23876 WP_001054376.1 NC_012759:c4470811-4470554 [Escherichia coli BW2952]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T23876 NC_012759:c4470811-4470554 [Escherichia coli BW2952]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT23876 WP_001309181.1 NC_012759:c4470542-4469997 [Escherichia coli BW2952]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT23876 NC_012759:c4470542-4469997 [Escherichia coli BW2952]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References