186996

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 1045931..1046745 Replicon chromosome
Accession NZ_CP068279
Organism Escherichia coli strain CY708

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JJW05_RS04985 Protein ID WP_001054376.1
Coordinates 1046488..1046745 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JJW05_RS04980 Protein ID WP_001309181.1
Coordinates 1045931..1046476 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJW05_RS04950 (1041622) 1041622..1042935 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
JJW05_RS04955 (1042947) 1042947..1043225 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
JJW05_RS04960 (1043222) 1043222..1044343 - 1122 WP_000010829.1 M42 family metallopeptidase -
JJW05_RS04965 (1044588) 1044588..1044704 - 117 Protein_963 VOC family protein -
JJW05_RS04970 (1044742) 1044742..1044960 - 219 Protein_964 hypothetical protein -
JJW05_RS04975 (1045129) 1045129..1045875 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JJW05_RS04980 (1045931) 1045931..1046476 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
JJW05_RS04985 (1046488) 1046488..1046745 - 258 WP_001054376.1 YjhX family toxin Toxin
JJW05_RS22910 (1047236) 1047236..1047367 - 132 WP_001309182.1 hypothetical protein -
JJW05_RS04995 (1047483) 1047483..1048723 + 1241 Protein_969 helicase YjhR -
JJW05_RS22915 (1048991) 1048991..1049196 - 206 Protein_970 HNH endonuclease -
JJW05_RS05000 (1049306) 1049306..1050286 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JJW05_RS05005 (1050351) 1050351..1051457 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 1045931..1057720 11789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T186996 WP_001054376.1 NZ_CP068279:c1046745-1046488 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T186996 NZ_CP089776:c703509-703096 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT186996 WP_001309181.1 NZ_CP068279:c1046476-1045931 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT186996 NZ_CP089776:c703742-703506 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References