103780

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 669746..670560 Replicon chromosome
Accession NZ_CP028760
Organism Escherichia coli strain A14

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag AOY67_RS03230 Protein ID WP_001054376.1
Coordinates 670303..670560 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag AOY67_RS03225 Protein ID WP_001309181.1
Coordinates 669746..670291 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY67_RS03195 (665437) 665437..666750 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
AOY67_RS03200 (666762) 666762..667040 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
AOY67_RS03205 (667037) 667037..668158 - 1122 WP_000010829.1 M42 family metallopeptidase -
AOY67_RS03210 (668403) 668403..668519 - 117 Protein_611 VOC family protein -
AOY67_RS03215 (668557) 668557..668775 - 219 Protein_612 hypothetical protein -
AOY67_RS03220 (668944) 668944..669690 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
AOY67_RS03225 (669746) 669746..670291 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
AOY67_RS03230 (670303) 670303..670560 - 258 WP_001054376.1 YjhX family toxin Toxin
AOY67_RS03235 (671051) 671051..671182 - 132 WP_001309182.1 hypothetical protein -
AOY67_RS03240 (671298) 671298..672538 + 1241 Protein_617 helicase YjhR -
AOY67_RS03245 (672806) 672806..673011 - 206 Protein_618 HNH endonuclease -
AOY67_RS03250 (673121) 673121..674101 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
AOY67_RS03255 (674166) 674166..675272 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 669746..681536 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T103780 WP_001054376.1 NZ_CP028760:c670560-670303 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T103780 NZ_CP028760:c670560-670303 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT103780 WP_001309181.1 NZ_CP028760:c670291-669746 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT103780 NZ_CP028760:c670291-669746 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References