Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4523130..4523944 Replicon chromosome
Accession NZ_CP032679
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag D7U33_RS21785 Protein ID WP_001054376.1
Coordinates 4523687..4523944 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag D7U33_RS21780 Protein ID WP_001309181.1
Coordinates 4523130..4523675 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7U33_RS21750 4518821..4520134 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
D7U33_RS21755 4520146..4520424 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
D7U33_RS21760 4520421..4521542 - 1122 WP_000010829.1 M42 family metallopeptidase -
D7U33_RS21765 4521787..4521903 - 117 Protein_4233 VOC family protein -
D7U33_RS21770 4521941..4522159 - 219 Protein_4234 hypothetical protein -
D7U33_RS21775 4522328..4523074 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
D7U33_RS21780 4523130..4523675 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
D7U33_RS21785 4523687..4523944 - 258 WP_001054376.1 hypothetical protein Toxin
D7U33_RS21790 4524321..4524566 - 246 Protein_4238 GNAT family N-acetyltransferase -
D7U33_RS21795 4524936..4525922 + 987 WP_001323209.1 hypothetical protein -
D7U33_RS21800 4526505..4527485 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
D7U33_RS21805 4527550..4528656 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4523130..4534920 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T112129 WP_001054376.1 NZ_CP032679:c4523944-4523687 [Escherichia coli str. K-12 substr. MG1655]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T112129 NZ_CP032679:c4523944-4523687 [Escherichia coli str. K-12 substr. MG1655]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT112129 WP_001309181.1 NZ_CP032679:c4523675-4523130 [Escherichia coli str. K-12 substr. MG1655]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT112129 NZ_CP032679:c4523675-4523130 [Escherichia coli str. K-12 substr. MG1655]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References