150918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3906160..3906974 Replicon chromosome
Accession NZ_CP049196
Organism Escherichia coli strain E118

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag G5T40_RS18700 Protein ID WP_001054376.1
Coordinates 3906160..3906417 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag G5T40_RS18705 Protein ID WP_001309181.1
Coordinates 3906429..3906974 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5T40_RS18680 3901448..3902554 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
G5T40_RS18685 3902619..3903599 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
G5T40_RS18690 3904182..3905422 - 1241 Protein_3651 DNA helicase -
G5T40_RS18695 3905538..3905783 + 246 Protein_3652 GNAT family N-acetyltransferase -
G5T40_RS18700 3906160..3906417 + 258 WP_001054376.1 hypothetical protein Toxin
G5T40_RS18705 3906429..3906974 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
G5T40_RS18710 3907030..3907776 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
G5T40_RS18715 3907945..3908163 + 219 Protein_3656 hypothetical protein -
G5T40_RS25220 3908201..3908317 + 117 Protein_3657 VOC family protein -
G5T40_RS18720 3908562..3909683 + 1122 WP_000010829.1 M42 family metallopeptidase -
G5T40_RS18725 3909680..3909958 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
G5T40_RS18730 3909970..3911282 + 1313 Protein_3660 permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 3895947..3906974 11027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T150918 WP_001054376.1 NZ_CP049196:3906160-3906417 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T150918 NZ_CP065146:3573174-3573560 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT150918 WP_001309181.1 NZ_CP049196:3906429-3906974 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT150918 NZ_CP065146:3573553-3573873 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGAATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References