139617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 683687..684501 Replicon chromosome
Accession NZ_CP043950
Organism Escherichia coli strain ST95-32

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag F3J96_RS03485 Protein ID WP_001054376.1
Coordinates 684244..684501 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag F3J96_RS03480 Protein ID WP_001350781.1
Coordinates 683687..684232 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3J96_RS03455 679378..680691 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
F3J96_RS03460 680703..680981 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
F3J96_RS03465 680978..682099 - 1122 WP_000010829.1 M42 family metallopeptidase -
F3J96_RS27705 682344..682460 - 117 Protein_637 VOC family protein -
F3J96_RS03470 682498..682716 - 219 Protein_638 hypothetical protein -
F3J96_RS03475 682885..683631 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
F3J96_RS03480 683687..684232 - 546 WP_001350781.1 N-acetyltransferase Antitoxin
F3J96_RS03485 684244..684501 - 258 WP_001054376.1 hypothetical protein Toxin
F3J96_RS03490 684878..685123 - 246 Protein_642 GNAT family N-acetyltransferase -
F3J96_RS03495 685239..686479 + 1241 Protein_643 helicase YjhR -
F3J96_RS03500 687062..688042 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
F3J96_RS03505 688107..689213 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 683687..695478 11791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T139617 WP_001054376.1 NZ_CP043950:c684501-684244 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T139617 NZ_CP058752:c2492604-2492287 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT139617 WP_001350781.1 NZ_CP043950:c684232-683687 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT139617 NZ_CP058752:c2492294-2492007 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACGTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References