225215

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 584569..585383 Replicon chromosome
Accession NZ_CP087287
Organism Escherichia coli strain APEC 16-1068

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag LO742_RS02840 Protein ID WP_001054376.1
Coordinates 585126..585383 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag LO742_RS02835 Protein ID WP_001350781.1
Coordinates 584569..585114 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO742_RS02805 (580260) 580260..581573 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
LO742_RS02810 (581585) 581585..581863 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
LO742_RS02815 (581860) 581860..582981 - 1122 WP_000010832.1 M42 family metallopeptidase -
LO742_RS02820 (583226) 583226..583342 - 117 Protein_546 VOC family protein -
LO742_RS02825 (583380) 583380..583598 - 219 Protein_547 hypothetical protein -
LO742_RS02830 (583767) 583767..584513 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
LO742_RS02835 (584569) 584569..585114 - 546 WP_001350781.1 N-acetyltransferase Antitoxin
LO742_RS02840 (585126) 585126..585383 - 258 WP_001054376.1 YjhX family toxin Toxin
LO742_RS02845 (585874) 585874..586005 - 132 WP_001309182.1 hypothetical protein -
LO742_RS02850 (586121) 586121..587361 + 1241 Protein_552 helicase YjhR -
LO742_RS02855 (587629) 587629..587834 - 206 Protein_553 HNH endonuclease -
LO742_RS02860 (587944) 587944..588924 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
LO742_RS02865 (588989) 588989..590095 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 584569..596362 11793


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T225215 WP_001054376.1 NZ_CP087287:c585383-585126 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T225215 NZ_CP121074:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTACCGCCTGTTTGTGGATGTGCAGAGCGACATCGTCGATAC
CCCTGGCCGGCGAATGGTGATCCCGCTGGCCAGTGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCGGTGG
TGCATATCGGGGATGAGAGCTGGCGTCTGATGACCACGGATATGGCCAGTGTCCCGGCCTCATTCATCGGGGAAGAGGTG
GCCGAGCTCAGCCACAGGGAGAACGACATCAAAAACGCCATTAACCTGATGTTCTGGGGGATCTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT225215 WP_001350781.1 NZ_CP087287:c585114-584569 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT225215 NZ_CP121074:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAAGCAGCGTATTACTGTCACCATAGACAGTGACAGCTATCAGTTACTCAAGTCCGCAGACGTGAATATCTCCGGCCT
GGTAAATACTGCCATGCAGAAGGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAGCGAACGGCTCCTTTGCAGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References