Detailed information of TA system TA034931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4506826..4507640
• Replicon: chromosome
• Accession: NZ_AP022207
• Organism: Escherichia coli strain WP7-S18-ESBL-09

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: H7R37_RS21690
• Protein ID: WP_001054376.1
• Coordinates: 4506826..4507083 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: H7R37_RS21695
• Protein ID: WP_001309181.1
• Coordinates: 4507095..4507640 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R37_RS21670	4502114..4503220	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
H7R37_RS21675	4503285..4504265	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
H7R37_RS21680	4504848..4506088	-	1241	Protein_4240	DNA helicase	-
H7R37_RS21685	4506204..4506449	+	246	Protein_4241	GNAT family N-acetyltransferase	-
H7R37_RS21690	4506826..4507083	+	258	WP_001054376.1	hypothetical protein	Toxin
H7R37_RS21695	4507095..4507640	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
H7R37_RS21700	4507696..4508442	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
H7R37_RS21705	4508611..4508829	+	219	Protein_4245	hypothetical protein	-
H7R37_RS26365	4508867..4508983	+	117	Protein_4246	VOC family protein	-
H7R37_RS21710	4509228..4510349	+	1122	WP_000010829.1	M42 family metallopeptidase	-
H7R37_RS21715	4510346..4510624	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H7R37_RS21720	4510636..4511949	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View HG738867 Escherichia coli str. K-12 substr. MC4100 Genomic island TA020089 4419085..4430625 0.007 View NC_000913 Escherichia coli str. K-12 substr. MG1655 Genomic island TA006279 4533239..4545029 0.002 View NC_007779 Escherichia coli str. K-12 substr. W3110 Genomic island TA021460 4537919..4549709 0.002 View NC_012759 Escherichia coli BW2952 Genomic island TA023876 4469997..4481537 0.007 View NC_017638 Escherichia coli DH1 Genomic island TA027426 4513009..4524807 0.003 View NZ_CP009273 Escherichia coli BW25113 Genomic island TA048705 4523056..4534846 0.002 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Genomic island TA068445 4432698..4444488 0.002 View NZ_HG738867 Escherichia coli str. K-12 substr. MC4100 strain K-12 Genomic island TA285034 4419085..4430625 0.007	inside	Genomic island	-	fimI / fimA / fimE / fimB	4496613..4507640	11027

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T34931 WP_001054376.1 NZ_AP022207:4506826-4507083 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T34931 NZ_AP022207:4506826-4507083 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT34931 WP_001309181.1 NZ_AP022207:4507095-4507640 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT34931 NZ_AP022207:4507095-4507640 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8