Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2332634..2333448 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QCG47_RS11160 Protein ID WP_001054376.1
Coordinates 2333191..2333448 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QCG47_RS11155 Protein ID WP_001309181.1
Coordinates 2332634..2333179 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS11125 (2328325) 2328325..2329638 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
QCG47_RS11130 (2329650) 2329650..2329928 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QCG47_RS11135 (2329925) 2329925..2331046 - 1122 WP_000010829.1 M42 family metallopeptidase -
QCG47_RS11140 (2331291) 2331291..2331407 - 117 Protein_2156 VOC family protein -
QCG47_RS11145 (2331445) 2331445..2331663 - 219 Protein_2157 hypothetical protein -
QCG47_RS11150 (2331832) 2331832..2332578 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QCG47_RS11155 (2332634) 2332634..2333179 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
QCG47_RS11160 (2333191) 2333191..2333448 - 258 WP_001054376.1 YjhX family toxin Toxin
QCG47_RS11165 (2333939) 2333939..2334070 - 132 WP_001309182.1 hypothetical protein -
QCG47_RS11170 (2334186) 2334186..2335426 + 1241 Protein_2162 helicase YjhR -
QCG47_RS11175 (2335694) 2335694..2335899 - 206 Protein_2163 HNH endonuclease -
QCG47_RS11180 (2336009) 2336009..2336989 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QCG47_RS11185 (2337054) 2337054..2338160 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 2332634..2344424 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T276757 WP_001054376.1 NZ_CP122319:c2333448-2333191 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT276757 WP_001309181.1 NZ_CP122319:c2333179-2332634 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References