Detailed information of TA system TA211162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4941118..4941932
• Replicon: chromosome
• Accession: NZ_CP080163
• Organism: Escherichia coli strain PK8275

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: KZY08_RS23655
• Protein ID: WP_001054376.1
• Coordinates: 4941118..4941375 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: KZY08_RS23660
• Protein ID: WP_001309181.1
• Coordinates: 4941387..4941932 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZY08_RS23635 (4936406)	4936406..4937512	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
KZY08_RS23640 (4937577)	4937577..4938557	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
KZY08_RS28285 (4938667)	4938667..4938872	+	206	Protein_4642	HNH endonuclease	-
KZY08_RS23645 (4939140)	4939140..4940380	-	1241	Protein_4643	helicase YjhR	-
KZY08_RS28290 (4940496)	4940496..4940627	+	132	WP_001309182.1	hypothetical protein	-
KZY08_RS23655 (4941118)	4941118..4941375	+	258	WP_001054376.1	YjhX family toxin	Toxin
KZY08_RS23660 (4941387)	4941387..4941932	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
KZY08_RS23665 (4941988)	4941988..4942734	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
KZY08_RS23670 (4942903)	4942903..4943121	+	219	Protein_4648	hypothetical protein	-
KZY08_RS23675 (4943159)	4943159..4943275	+	117	Protein_4649	VOC family protein	-
KZY08_RS23680 (4943520)	4943520..4944641	+	1122	WP_000010829.1	M42 family metallopeptidase	-
KZY08_RS23685 (4944638)	4944638..4944916	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
KZY08_RS23690 (4944928)	4944928..4946241	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View HG738867 Escherichia coli str. K-12 substr. MC4100 Genomic island TA020089 4419085..4430625 0.007 View NC_000913 Escherichia coli str. K-12 substr. MG1655 Genomic island TA006279 4533239..4545029 0.002 View NC_007779 Escherichia coli str. K-12 substr. W3110 Genomic island TA021460 4537919..4549709 0.002 View NC_012759 Escherichia coli BW2952 Genomic island TA023876 4469997..4481537 0.007 View NC_017638 Escherichia coli DH1 Genomic island TA027426 4513009..4524807 0.003 View NZ_CP009273 Escherichia coli BW25113 Genomic island TA048705 4523056..4534846 0.002 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Genomic island TA068445 4432698..4444488 0.002 View NZ_HG738867 Escherichia coli str. K-12 substr. MC4100 strain K-12 Genomic island TA285034 4419085..4430625 0.007	inside	Genomic island	-	fimI / fimA / fimE / fimB	4930904..4941932	11028

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T211162 WP_001054376.1 NZ_CP080163:4941118-4941375 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T211162 NZ_CP104727:c4429077-4428739 [Pseudomonas citronellolis]
ATGATTTCGAAAACGCTCGGCGCGGATGGCGCCGAGGCCTTTTACCGCATCATCGTGCCGGCTTATGCCGGCATGCCTTT
GTCTGGGATGGGGGCAGCGTGTCAGGGAGGACGGTTCAATCGTCCTGACCAGGAGGCGTTGTACCTGGCACTGGATGAAG
CGACGGCGCTGGCTGAATGCAAGCAGGACAATCCTTGGATACGCCTTGGCACGATCTGCACGCTCTTCGTCAATGGCCTG
CGCGTTGCTGACTTGAGCGCCGGTTTCGTTCCGGATCGCTGGCCGCCGCTCTGGGCTGATTACACAGTGGATTGGCGAGC
AGAGTGGTTTGACAAGTAG

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT211162 WP_001309181.1 NZ_CP080163:4941387-4941932 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT211162 NZ_CP104727:c4429445-4429074 [Pseudomonas citronellolis]
ATGGACACTGTATTGCAAGAACCCTTCGTTGAGCGGTTCCGCGAGCCGAATACTCCGTATCTGTCTCCATCCAAGGTGGG
AGACTTCTTTGGCTTTCGAGTGCACGAGTTAGCCGAGCGTGCGCATGTGCACCGCAATACTCCGACTGCACGGCCCCATG
CGCCGCAGTTGCAGAAGTACCTGCAGGATATGGTGCGGGTGCTCGCGGTGGCCACTGAGATGACCGGTGACGTTCAGCGG
GCGGTTTTCCTGCTGCGCAATGAGCCGCTTCGGGCTTTTGGCTACAAGACCGCCGACACCTTGATTCAGGAAGGGCGGGC
CGATGCAGTCATTGCCTACTTGGAGTCCTTCGCCGGCGGTGCCGCCGGATGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8