287182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3928752..3929566 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name yjhX Uniprot ID -
Locus tag EL093_RS19100 Protein ID WP_126323161.1
Coordinates 3928752..3929009 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag EL093_RS19105 Protein ID WP_001309181.1
Coordinates 3929021..3929566 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS19080 3924040..3925146 + 1107 WP_023568191.1 N-acetylneuraminate epimerase -
EL093_RS19085 3925211..3926191 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EL093_RS19090 3926774..3928014 - 1241 Protein_3708 helicase YjhR -
EL093_RS19095 3928130..3928375 + 246 Protein_3709 GNAT family N-acetyltransferase -
EL093_RS19100 3928752..3929009 + 258 WP_126323161.1 YjhX family toxin Toxin
EL093_RS19105 3929021..3929566 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
EL093_RS19110 3929622..3930368 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EL093_RS19115 3930405..3931247 + 843 Protein_3713 xylonate dehydratase YjhG -
EL093_RS19120 3931354..3932703 + 1350 WP_001128363.1 GntP family permease -
EL093_RS19125 3933050..3934036 + 987 WP_000373366.1 sugar-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 3918538..3929566 11028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9748.32 Da        Isoelectric Point: 11.0090

>T287182 WP_126323161.1 NZ_LR134227:3928752-3929009 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRITSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT287182 WP_001309181.1 NZ_LR134227:3929021-3929566 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References