225494

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3894246..3895060 Replicon chromosome
Accession NZ_CP087564
Organism Escherichia coli strain CM2010-0578/1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag LOF66_RS19505 Protein ID WP_001054376.1
Coordinates 3894803..3895060 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag LOF66_RS19500 Protein ID WP_001309181.1
Coordinates 3894246..3894791 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOF66_RS19470 (3889937) 3889937..3891250 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
LOF66_RS19475 (3891262) 3891262..3891540 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
LOF66_RS19480 (3891537) 3891537..3892658 - 1122 WP_000010829.1 M42 family metallopeptidase -
LOF66_RS19485 (3892903) 3892903..3893019 - 117 Protein_3804 VOC family protein -
LOF66_RS19490 (3893057) 3893057..3893275 - 219 Protein_3805 hypothetical protein -
LOF66_RS19495 (3893444) 3893444..3894190 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
LOF66_RS19500 (3894246) 3894246..3894791 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
LOF66_RS19505 (3894803) 3894803..3895060 - 258 WP_001054376.1 YjhX family toxin Toxin
LOF66_RS19510 (3895551) 3895551..3895682 - 132 WP_001309182.1 hypothetical protein -
LOF66_RS19515 (3895798) 3895798..3897038 + 1241 Protein_3810 helicase YjhR -
LOF66_RS19520 (3897306) 3897306..3897511 - 206 Protein_3811 HNH endonuclease -
LOF66_RS19525 (3897621) 3897621..3898601 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
LOF66_RS19530 (3898666) 3898666..3899772 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 3894246..3906038 11792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T225494 WP_001054376.1 NZ_CP087564:c3895060-3894803 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T225494 NZ_CP121153:3696796-3697338 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT225494 WP_001309181.1 NZ_CP087564:c3894791-3894246 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT225494 NZ_CP121153:3696501-3696812 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References