Detailed information of TA system TA230206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4415295..4416109
• Replicon: chromosome
• Accession: NZ_CP090196
• Organism: Escherichia coli strain YL3

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: LXN07_RS21170
• Protein ID: WP_001054376.1
• Coordinates: 4415295..4415552 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: LXN07_RS21175
• Protein ID: WP_001309181.1
• Coordinates: 4415564..4416109 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXN07_RS21145 (4410583)	4410583..4411689	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
LXN07_RS21150 (4411754)	4411754..4412734	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
LXN07_RS21155 (4412844)	4412844..4413049	+	206	Protein_4141	HNH endonuclease	-
LXN07_RS21160 (4413317)	4413317..4414557	-	1241	Protein_4142	helicase YjhR	-
LXN07_RS21165 (4414673)	4414673..4414804	+	132	WP_001309182.1	hypothetical protein	-
LXN07_RS21170 (4415295)	4415295..4415552	+	258	WP_001054376.1	YjhX family toxin	Toxin
LXN07_RS21175 (4415564)	4415564..4416109	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
LXN07_RS21180 (4416165)	4416165..4416911	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
LXN07_RS21185 (4417080)	4417080..4417298	+	219	Protein_4147	hypothetical protein	-
LXN07_RS21190 (4417336)	4417336..4417452	+	117	Protein_4148	VOC family protein	-
LXN07_RS21195 (4417697)	4417697..4418818	+	1122	WP_000010829.1	M42 family metallopeptidase	-
LXN07_RS21200 (4418815)	4418815..4419093	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
LXN07_RS21205 (4419105)	4419105..4420418	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View HG738867 Escherichia coli str. K-12 substr. MC4100 Genomic island TA020089 4419085..4430625 0.007 View NC_000913 Escherichia coli str. K-12 substr. MG1655 Genomic island TA006279 4533239..4545029 0.002 View NC_007779 Escherichia coli str. K-12 substr. W3110 Genomic island TA021460 4537919..4549709 0.002 View NC_012759 Escherichia coli BW2952 Genomic island TA023876 4469997..4481537 0.007 View NC_017638 Escherichia coli DH1 Genomic island TA027426 4513009..4524807 0.003 View NZ_CP009273 Escherichia coli BW25113 Genomic island TA048705 4523056..4534846 0.002 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Genomic island TA068445 4432698..4444488 0.002 View NZ_HG738867 Escherichia coli str. K-12 substr. MC4100 strain K-12 Genomic island TA285034 4419085..4430625 0.007	inside	Genomic island	-	fimI / fimA / fimE / fimB	4405082..4416109	11027

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T230206 WP_001054376.1 NZ_CP090196:4415295-4415552 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T230206 NZ_CP124754:c3374483-3374130 [Serratia sp. K-E0102]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGATCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTACTTTGCGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCGGATGATTCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT230206 WP_001309181.1 NZ_CP090196:4415564-4416109 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT230206 NZ_CP124754:c3374125-3373823 [Serratia sp. K-E0102]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCTGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCAACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTCAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCGGACGGCTCTCACTACGAATTTGTGCTGTAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8