255942

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4417576..4418390 Replicon chromosome
Accession NZ_CP103633
Organism Escherichia coli strain 2900

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag M5S90_RS21200 Protein ID WP_001054376.1
Coordinates 4417576..4417833 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag M5S90_RS21205 Protein ID WP_001309181.1
Coordinates 4417845..4418390 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S90_RS21175 (4412864) 4412864..4413970 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
M5S90_RS21180 (4414035) 4414035..4415015 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
M5S90_RS21185 (4415125) 4415125..4415330 + 206 Protein_4145 HNH endonuclease -
M5S90_RS21190 (4415598) 4415598..4416838 - 1241 Protein_4146 helicase YjhR -
M5S90_RS21195 (4416954) 4416954..4417085 + 132 WP_001309182.1 hypothetical protein -
M5S90_RS21200 (4417576) 4417576..4417833 + 258 WP_001054376.1 YjhX family toxin Toxin
M5S90_RS21205 (4417845) 4417845..4418390 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
M5S90_RS21210 (4418446) 4418446..4419192 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
M5S90_RS21215 (4419361) 4419361..4419579 + 219 Protein_4151 hypothetical protein -
M5S90_RS21220 (4419617) 4419617..4419733 + 117 Protein_4152 VOC family protein -
M5S90_RS21225 (4419978) 4419978..4421099 + 1122 WP_000010829.1 M42 family metallopeptidase -
M5S90_RS21230 (4421096) 4421096..4421374 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
M5S90_RS21235 (4421386) 4421386..4422699 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 4407363..4418390 11027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T255942 WP_001054376.1 NZ_CP103633:4417576-4417833 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT255942 WP_001309181.1 NZ_CP103633:4417845-4418390 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References