190816

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3474970..3475784 Replicon chromosome
Accession NZ_CP069528
Organism Escherichia coli strain FDAARGOS_1252

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag I6J82_RS16685 Protein ID WP_001054376.1
Coordinates 3474970..3475227 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag I6J82_RS16690 Protein ID WP_001540600.1
Coordinates 3475239..3475784 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J82_RS16665 3470258..3471364 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
I6J82_RS16670 3471429..3472409 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
I6J82_RS16675 3472992..3474232 - 1241 Protein_3261 DNA helicase -
I6J82_RS16680 3474348..3474593 + 246 Protein_3262 GNAT family N-acetyltransferase -
I6J82_RS16685 3474970..3475227 + 258 WP_001054376.1 hypothetical protein Toxin
I6J82_RS16690 3475239..3475784 + 546 WP_001540600.1 N-acetyltransferase Antitoxin
I6J82_RS16695 3475840..3476586 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
I6J82_RS16700 3476755..3476973 + 219 Protein_3266 hypothetical protein -
I6J82_RS16705 3477011..3477127 + 117 Protein_3267 VOC family protein -
I6J82_RS16710 3477372..3478493 + 1122 WP_000010829.1 M42 family metallopeptidase -
I6J82_RS16715 3478490..3478768 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
I6J82_RS16720 3478780..3480093 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 3464756..3475784 11028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T190816 WP_001054376.1 NZ_CP069528:3474970-3475227 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T190816 NZ_CP091556:3427371-3427589 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT190816 WP_001540600.1 NZ_CP069528:3475239-3475784 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT190816 NZ_CP091556:3426969-3427343 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References