181449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4523057..4523871 Replicon chromosome
Accession NZ_CP064678
Organism Escherichia coli K-12 strain CETR3G40

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag IVL03_RS21795 Protein ID WP_001054376.1
Coordinates 4523614..4523871 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag IVL03_RS21790 Protein ID WP_001309181.1
Coordinates 4523057..4523602 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVL03_RS21760 4518748..4520061 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
IVL03_RS21765 4520073..4520351 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
IVL03_RS21770 4520348..4521469 - 1122 WP_000010829.1 M42 family metallopeptidase -
IVL03_RS21775 4521714..4521830 - 117 Protein_4236 VOC family protein -
IVL03_RS21780 4521868..4522086 - 219 Protein_4237 hypothetical protein -
IVL03_RS21785 4522255..4523001 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
IVL03_RS21790 4523057..4523602 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
IVL03_RS21795 4523614..4523871 - 258 WP_001054376.1 hypothetical protein Toxin
IVL03_RS21800 4524248..4524493 - 246 Protein_4241 GNAT family N-acetyltransferase -
IVL03_RS21805 4524609..4525849 + 1241 Protein_4242 DNA helicase -
IVL03_RS21810 4526432..4527412 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
IVL03_RS21815 4527477..4528583 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4523057..4534847 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T181449 WP_001054376.1 NZ_CP064678:c4523871-4523614 [Escherichia coli K-12]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T181449 NZ_CP085860:4156685-4157029 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACCAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGACGCGGCCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGAGGGTTTTTCGCTTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACTGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT181449 WP_001309181.1 NZ_CP064678:c4523602-4523057 [Escherichia coli K-12]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT181449 NZ_CP085860:4157035-4157337 [Serratia marcescens]
ATGGCCAAACCGTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAGCTGCGGCTGGCAATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References