285415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4476447..4477261 Replicon chromosome
Accession NZ_LM993812
Organism Escherichia coli strain K-12 substr. HMS174

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ECHMS174_RS22085 Protein ID WP_001054376.1
Coordinates 4477004..4477261 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ECHMS174_RS22080 Protein ID WP_001309181.1
Coordinates 4476447..4476992 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECHMS174_RS22060 4472138..4473451 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
ECHMS174_RS22065 4473463..4473741 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECHMS174_RS22070 4473738..4474859 - 1122 WP_000010829.1 M42 family metallopeptidase -
ECHMS174_RS25775 4475104..4475220 - 117 Protein_4180 VOC family protein -
ECHMS174_RS25115 4475258..4475476 - 219 Protein_4181 hypothetical protein -
ECHMS174_RS22075 4475645..4476391 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ECHMS174_RS22080 4476447..4476992 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
ECHMS174_RS22085 4477004..4477261 - 258 WP_001054376.1 hypothetical protein Toxin
ECHMS174_RS25575 4477638..4477883 - 246 Protein_4185 GNAT family N-acetyltransferase -
ECHMS174_RS22100 4477999..4479239 + 1241 Protein_4186 helicase YjhR -
ECHMS174_RS22105 4479822..4480802 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECHMS174_RS22110 4480867..4481973 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4476447..4488237 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T285415 WP_001054376.1 NZ_LM993812:c4477261-4477004 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT285415 WP_001309181.1 NZ_LM993812:c4476992-4476447 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References