Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 598956..599770 Replicon chromosome
Accession NZ_CP044410
Organism Escherichia coli strain ecMN1F

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag FNW43_RS02820 Protein ID WP_001054376.1
Coordinates 599513..599770 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag FNW43_RS02815 Protein ID WP_001309181.1
Coordinates 598956..599501 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNW43_RS02790 594647..595960 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
FNW43_RS02795 595972..596250 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
FNW43_RS02800 596247..597368 - 1122 WP_000010829.1 M42 family metallopeptidase -
FNW43_RS22630 597613..597729 - 117 Protein_523 VOC family protein -
FNW43_RS02805 597767..597985 - 219 Protein_524 hypothetical protein -
FNW43_RS02810 598154..598900 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
FNW43_RS02815 598956..599501 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
FNW43_RS02820 599513..599770 - 258 WP_001054376.1 hypothetical protein Toxin
FNW43_RS02825 600147..600392 - 246 Protein_528 GNAT family N-acetyltransferase -
FNW43_RS02830 600508..601748 + 1241 Protein_529 DNA helicase -
FNW43_RS02835 602331..603311 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
FNW43_RS02840 603376..604482 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 598956..610746 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T140872 WP_001054376.1 NZ_CP044410:c599770-599513 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T140872 NZ_CP059488:1836899-1837471 [Acidithiobacillus ferrivorans]
ATGAGTTCGAACTTCATCGTCATCTACGACGCGTGCGTGCTCTACCCGGCACCGTTGCGCGACATGCTGATGCGTCTGGC
GCTGACCGATCTGTACCGGGCGCGTTGGACGGACATGATCCACGACGAGTGGACGCGTAACGTTCTGAAGCAGCGGCCAG
ACCTGAAGGCCGAAGACCTGGAGCGGACGCGGTCGTTGATGAACGCCCACGTCCGCGACAGCCTGGTCACCGGCTTCGAG
CATCTGATCCCGTCCGTCGAGTTGCCGGACGCCGATGACCGGCATGTGGTGGCTGCCGCTATTCACGGCGGTGCCAGTCT
GATCGTGACGTTCAACCTGAAGGATTTTCCGCCGGAACGGCTCAAACCGTACAATCTGACCGCCCAGCATCCCGATGACT
TCATCTTCGATCTACTGGATCTGCACGCAGCCCGCGTTTGCGAGGCAGCGGCCAACCATCGACGATCGCTGAAGAACCCG
CCCAAGACGGTTGACGAGTACCTGGACACGCTGCTCAAGCAGGGACTGACACAGACCGTCGGCCAGTTGCGGGAGTGGAA
GGTAGCGATCTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT140872 WP_001309181.1 NZ_CP044410:c599501-598956 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT140872 NZ_CP059488:1836434-1836898 [Acidithiobacillus ferrivorans]
ATGACCACACTCTCTCCCACCCATTCGTTGCCGACGGCCGAAGAAGTTGCCATCGCCCGCGAGAGCGGCCGGGCGCTGTC
CGCCTTCCTTCAGACCCGAGCGGAAACCCAGCAGATCGAGATATTCAACGACAAGGGCGCGTCTCATTCGGTCCGCGTCC
CGGTGTCGGCGCTGCGCCTTCTCGTGGACGTACTGACCGAAATCGGTGAGGGCAACGCGGTCAGTATCATCCCGATCCAC
GCCGAACTGACAACGCAAGACGCAGCGGACGTACTCAATGTCTCGCGACCGTTCCTCGTCCAGTTGCTGGAGCGCGGCGA
GATCCCGTTCCACAAGATCGGTACTCACCGTCGTGTCCGCTACCAGGACGTGATCGCGTACAAGGAGCGGATCGACGCTG
AGCGCAGCAAGGCCCTTGATGCACTGGCCGAGCAAGCCCAGGCGCTCAAGATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References