181621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4523056..4523870 Replicon chromosome
Accession NZ_CP064682
Organism Escherichia coli K-12 strain BZKR2G40

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag IVK99_RS21800 Protein ID WP_001054376.1
Coordinates 4523613..4523870 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag IVK99_RS21795 Protein ID WP_001309181.1
Coordinates 4523056..4523601 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVK99_RS21765 4518747..4520060 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
IVK99_RS21770 4520072..4520350 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
IVK99_RS21775 4520347..4521468 - 1122 WP_000010829.1 M42 family metallopeptidase -
IVK99_RS21780 4521713..4521829 - 117 Protein_4237 VOC family protein -
IVK99_RS21785 4521867..4522085 - 219 Protein_4238 hypothetical protein -
IVK99_RS21790 4522254..4523000 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
IVK99_RS21795 4523056..4523601 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
IVK99_RS21800 4523613..4523870 - 258 WP_001054376.1 hypothetical protein Toxin
IVK99_RS21805 4524247..4524492 - 246 Protein_4242 GNAT family N-acetyltransferase -
IVK99_RS21810 4524608..4525848 + 1241 Protein_4243 DNA helicase -
IVK99_RS21815 4526431..4527411 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
IVK99_RS21820 4527476..4528582 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4523056..4534847 11791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T181621 WP_001054376.1 NZ_CP064682:c4523870-4523613 [Escherichia coli K-12]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T181621 NZ_CP085984:c72825-72409 [Salmonella enterica]
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT181621 WP_001309181.1 NZ_CP064682:c4523601-4523056 [Escherichia coli K-12]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT181621 NZ_CP085984:c73052-72822 [Salmonella enterica]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References