289531

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4516733..4517547 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag IEU92_RS21760 Protein ID WP_001054376.1
Coordinates 4517290..4517547 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag IEU92_RS21755 Protein ID WP_001309181.1
Coordinates 4516733..4517278 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS21725 4512424..4513737 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
IEU92_RS21730 4513749..4514027 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
IEU92_RS21735 4514024..4515145 - 1122 WP_000010829.1 M42 family metallopeptidase -
IEU92_RS21740 4515390..4515506 - 117 Protein_4226 VOC family protein -
IEU92_RS21745 4515544..4515762 - 219 Protein_4227 hypothetical protein -
IEU92_RS21750 4515931..4516677 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
IEU92_RS21755 4516733..4517278 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
IEU92_RS21760 4517290..4517547 - 258 WP_001054376.1 hypothetical protein Toxin
IEU92_RS21765 4517924..4518169 - 246 Protein_4231 GNAT family N-acetyltransferase -
IEU92_RS21770 4518285..4519525 + 1241 Protein_4232 DNA helicase -
IEU92_RS21775 4520108..4521088 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
IEU92_RS21780 4521153..4522259 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4516733..4528523 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T289531 WP_001054376.1 NZ_LR881938:c4517547-4517290 [Escherichia coli str. K-12 substr. MG1655]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT289531 WP_001309181.1 NZ_LR881938:c4517278-4516733 [Escherichia coli str. K-12 substr. MG1655]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References