234490

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 573406..574220 Replicon chromosome
Accession NZ_CP091682
Organism Escherichia coli strain KKo003

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag L6L54_RS02755 Protein ID WP_001054376.1
Coordinates 573963..574220 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag L6L54_RS02750 Protein ID WP_001540600.1
Coordinates 573406..573951 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L54_RS02720 (569097) 569097..570410 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
L6L54_RS02725 (570422) 570422..570700 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
L6L54_RS02730 (570697) 570697..571818 - 1122 WP_000010829.1 M42 family metallopeptidase -
L6L54_RS02735 (572063) 572063..572179 - 117 Protein_531 VOC family protein -
L6L54_RS02740 (572217) 572217..572435 - 219 Protein_532 hypothetical protein -
L6L54_RS02745 (572604) 572604..573350 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
L6L54_RS02750 (573406) 573406..573951 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
L6L54_RS02755 (573963) 573963..574220 - 258 WP_001054376.1 YjhX family toxin Toxin
L6L54_RS02760 (574711) 574711..574842 - 132 WP_001309182.1 hypothetical protein -
L6L54_RS02765 (574958) 574958..576198 + 1241 Protein_537 helicase YjhR -
L6L54_RS02770 (576466) 576466..576671 - 206 Protein_538 HNH endonuclease -
L6L54_RS02775 (576781) 576781..577761 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
L6L54_RS02780 (577826) 577826..578932 - 1107 WP_001774143.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 573406..585196 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T234490 WP_001054376.1 NZ_CP091682:c574220-573963 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T234490 NZ_LR130546:94205-94480 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT234490 WP_001540600.1 NZ_CP091682:c573951-573406 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT234490 NZ_LR130546:93921-94205 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References