189941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4523052..4523866 Replicon chromosome
Accession NZ_CP069132
Organism Escherichia coli BW25113 substr. CHXR1G20

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JQK35_RS21800 Protein ID WP_001054376.1
Coordinates 4523609..4523866 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JQK35_RS21795 Protein ID WP_001309181.1
Coordinates 4523052..4523597 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQK35_RS21765 4518743..4520056 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
JQK35_RS21770 4520068..4520346 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JQK35_RS21775 4520343..4521464 - 1122 WP_000010829.1 M42 family metallopeptidase -
JQK35_RS21780 4521709..4521825 - 117 Protein_4237 VOC family protein -
JQK35_RS21785 4521863..4522081 - 219 Protein_4238 hypothetical protein -
JQK35_RS21790 4522250..4522996 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JQK35_RS21795 4523052..4523597 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
JQK35_RS21800 4523609..4523866 - 258 WP_001054376.1 hypothetical protein Toxin
JQK35_RS21805 4524243..4524488 - 246 Protein_4242 GNAT family N-acetyltransferase -
JQK35_RS21810 4524604..4525844 + 1241 Protein_4243 DNA helicase -
JQK35_RS21815 4526427..4527407 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JQK35_RS21820 4527472..4528578 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4523052..4534842 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T189941 WP_001054376.1 NZ_CP069132:c4523866-4523609 [Escherichia coli BW25113]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T189941 NZ_CP091029:1891410-1891661 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT189941 WP_001309181.1 NZ_CP069132:c4523597-4523052 [Escherichia coli BW25113]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT189941 NZ_CP091029:1891658-1891912 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References