Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4502468..4503282 Replicon chromosome
Accession NZ_CP011321
Organism Escherichia coli strain SQ88

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag SG49_RS22245 Protein ID WP_001054376.1
Coordinates 4503025..4503282 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag SG49_RS22240 Protein ID WP_001309181.1
Coordinates 4502468..4503013 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG49_RS22220 4498159..4499472 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
SG49_RS22225 4499484..4499762 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
SG49_RS22230 4499759..4500880 - 1122 WP_000010829.1 M42 family metallopeptidase -
SG49_RS25860 4501125..4501241 - 117 Protein_4239 VOC family protein -
SG49_RS25225 4501279..4501497 - 219 Protein_4240 hypothetical protein -
SG49_RS22235 4501666..4502412 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
SG49_RS22240 4502468..4503013 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
SG49_RS22245 4503025..4503282 - 258 WP_001054376.1 hypothetical protein Toxin
SG49_RS25670 4503659..4503904 - 246 Protein_4244 GNAT family N-acetyltransferase -
SG49_RS22260 4504020..4505260 + 1241 Protein_4245 helicase YjhR -
SG49_RS22265 4505843..4506823 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
SG49_RS22270 4506888..4507994 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4502468..4514258 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T53909 WP_001054376.1 NZ_CP011321:c4503282-4503025 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T53909 NZ_CP011321:c4503282-4503025 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT53909 WP_001309181.1 NZ_CP011321:c4503013-4502468 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT53909 NZ_CP011321:c4503013-4502468 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References