216393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4533103..4533917 Replicon chromosome
Accession NZ_CP083410
Organism Escherichia coli strain RP437

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag LAJ62_RS22000 Protein ID WP_001054376.1
Coordinates 4533660..4533917 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag LAJ62_RS21995 Protein ID WP_001309181.1
Coordinates 4533103..4533648 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ62_RS21965 (4528794) 4528794..4530107 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
LAJ62_RS21970 (4530119) 4530119..4530397 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
LAJ62_RS21975 (4530394) 4530394..4531515 - 1122 WP_000010829.1 M42 family metallopeptidase -
LAJ62_RS21980 (4531760) 4531760..4531876 - 117 Protein_4280 VOC family protein -
LAJ62_RS21985 (4531914) 4531914..4532132 - 219 Protein_4281 hypothetical protein -
LAJ62_RS21990 (4532301) 4532301..4533047 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
LAJ62_RS21995 (4533103) 4533103..4533648 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
LAJ62_RS22000 (4533660) 4533660..4533917 - 258 WP_001054376.1 YjhX family toxin Toxin
LAJ62_RS22005 (4534408) 4534408..4534539 - 132 WP_001309182.1 hypothetical protein -
LAJ62_RS22010 (4534655) 4534655..4535895 + 1241 Protein_4286 helicase YjhR -
LAJ62_RS22015 (4536163) 4536163..4536368 - 206 Protein_4287 HNH endonuclease -
LAJ62_RS22020 (4536478) 4536478..4537458 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
LAJ62_RS22025 (4537523) 4537523..4538629 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4533103..4544893 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T216393 WP_001054376.1 NZ_CP083410:c4533917-4533660 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T216393 NZ_CP113037:c2342021-2341770 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGACAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT216393 WP_001309181.1 NZ_CP083410:c4533648-4533103 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT216393 NZ_CP113037:c2341780-2341607 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAATCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References