Detailed information of TA system TA151641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 574399..575213
• Replicon: chromosome
• Accession: NZ_CP049839
• Organism: Escherichia coli strain UPEC-455U/190220

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: G9W36_RS02760
• Protein ID: WP_001054376.1
• Coordinates: 574956..575213 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: S1NWL7
• Locus tag: G9W36_RS02755
• Protein ID: WP_001540600.1
• Coordinates: 574399..574944 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9W36_RS02725 (570090)	570090..571403	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
G9W36_RS02730 (571415)	571415..571693	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
G9W36_RS02735 (571690)	571690..572811	-	1122	WP_000010829.1	M42 family metallopeptidase	-
G9W36_RS02740 (573056)	573056..573172	-	117	Protein_532	VOC family protein	-
G9W36_RS02745 (573210)	573210..573428	-	219	Protein_533	hypothetical protein	-
G9W36_RS02750 (573597)	573597..574343	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
G9W36_RS02755 (574399)	574399..574944	-	546	WP_001540600.1	N-acetyltransferase	Antitoxin
G9W36_RS02760 (574956)	574956..575213	-	258	WP_001054376.1	YjhX family toxin	Toxin
G9W36_RS25335 (575704)	575704..575835	-	132	WP_001309182.1	hypothetical protein	-
G9W36_RS02770 (575951)	575951..577191	+	1241	Protein_538	helicase YjhR	-
G9W36_RS25340 (577459)	577459..577664	-	206	Protein_539	HNH endonuclease	-
G9W36_RS02775 (577774)	577774..578754	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
G9W36_RS02780 (578819)	578819..579925	-	1107	WP_001774143.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View HG738867 Escherichia coli str. K-12 substr. MC4100 Genomic island TA020089 4419085..4430625 0.005 View NC_000913 Escherichia coli str. K-12 substr. MG1655 Genomic island TA006279 4533239..4545029 0.001 View NC_007779 Escherichia coli str. K-12 substr. W3110 Genomic island TA021460 4537919..4549709 0.001 View NC_012759 Escherichia coli BW2952 Genomic island TA023876 4469997..4481537 0.005 View NC_017638 Escherichia coli DH1 Genomic island TA027426 4513009..4524807 0.001 View NZ_CP009273 Escherichia coli BW25113 Genomic island TA048705 4523056..4534846 0.001 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Genomic island TA068445 4432698..4444488 0.001 View NZ_HG738867 Escherichia coli str. K-12 substr. MC4100 strain K-12 Genomic island TA285034 4419085..4430625 0.005	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	574399..586189	11790

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T151641 WP_001054376.1 NZ_CP049839:c575213-574956 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T151641 NZ_CP065626:202499-203416 [Edwardsiella hoshinae]
ATGGATAAAACCTCCCCCTACTACCGCCAGGTCGCCCTGCTGGTGCGCACATTACCCTATGTCGCTAACGAGGCCTGTTT
TGCGCTAAAAGGGGGAACGGCGATCAACTTATTCATCCGTGATTTTCCCCGATTGTCCGTTGATATCGATCTGGCCTACA
TCCCGCTGGAAAGCAGAGCGGTCGCCTTGCCCAACGTGCGGGAAGCGCTCACCCGCATCGCAACAGAACTGGAAACACAA
GCCGGGCTCAGCGCAGTGCTGCAAACCAATCATCCCGATGAGATGCGCATCATAGCCACCACGGACGACGCGCAAATTAA
AATAGAAGTCTCGCCAGTTGCCCGGGGAACCTTATATCCACCACAAGAACGCGACGTCGTGGAAGCTGTGGAGGAAGAAT
TTGGTTTTGCCGCGATCCCGGTGGTCTCACTACCTGATTTGTACGGCGGCAAGCTATGCGCTGCGTTAGATCGCCAGCAC
CCCAGAGATTTTTACGACGTCAAAATGCTCCTTGATACACAAGGGATCGATCGCACGATATTCAATGGATTTATCGCTTA
CTTGCTCAGCCATAATCGCCCCTTGTCCGAAGTGCTTAGCCCACGCTGGAAGGATATTACTGAACCCTTTCAAAATGAAT
TCAGCGGCATGACCTTTGAGGAAGTATCACTGGAAGAGCTAAGAGAGGTCCCGGAAAGAATGCTCAGCGCGTTGAAAGCG
CATTTTACGCAACAGGATTTCGACTTCCTGATGTCATTTAAACGCGGGGAGCCTGACTGGAATTTAGCACCAGAGCCCCA
CATTCAGAATTTGCCTGCCGTTCAATGGAAGCTGTGCAATATTGGACGGATGTCGGAAGAAAAGCACGCGCAGTCGCTGG
AGAAACTGGAACAGATCCTGGCAGAATGGCTAAGCTAG

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19926.87 Da
• Isoelectric Point: 6.3277

>AT151641 WP_001540600.1 NZ_CP049839:c574944-574399 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT151641 NZ_CP065626:201733-202506 [Edwardsiella hoshinae]
ATGTCGTCAAAAATAAACTGGCTGTTGCAAAATACCGCTCCGGGAAGCCTGGTTTTGCAATCCTGGCTGACCCGGAACGG
CATATCACCTTCTCTGGCCTTTAAATACGCGCAAAATGGCTGGTTGATAAAACGGCGGGCTGGTGTTTATGCGCGCGCAG
GACGGGAACCGGACTGGAGCGATGCGCTATGGTGTCTGCAAAACCAGCTTGAAGCGCCGGTGCATCTGGCCGGACTGAGT
AGTCTCTCCTGGCAGGGCCGTTCCCATTACCTACAGCTTAAGCAGAGTCAATGCTGGCTTAGTGTTGAAAACAAAATGAT
ATTACCCAAATGGTTTAAAGAATTTCCTGGCGTTGAGTGGCTGATAGTATCAGCTCTGAAGCTTCCTCAACTGGATGAGA
AGTTCCGAACCGAGCTTGAGGTTAAAGGGAAAAAAATAACCGCCAGCGTACCAGAACTGGCTGCCTATGAGCTGTTAAGC
GCAGTCCCTCAGGAAATCTCATTTGAGCACGCTGCCGAGCTTTTTCAGGGGTTGGTCAATCTCAACCCACGTAAAGTGGA
AAAGCTGCTTACGCTCAGCCAGTCCGTACAAATCAAGCGCCTGTATCTGTTTTTCGCCAGTTTCTATGAACATGCATGGT
TCAAACGCGTGGACACCAGCAGAATCGACCTAGGCACAGGCAAGCGACAAGTCGTGGTTAATGGCAGACTGAACACGCAA
TACCAGATTACTGTGCCCGAAAATTTTACTCAGCAGAGCATAAATCATGGATAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: S1NWL7