47531

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4610098..4610912 Replicon chromosome
Accession NZ_CP008801
Organism Escherichia coli KLY

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag HQ24_RS22820 Protein ID WP_001054376.1
Coordinates 4610655..4610912 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag HQ24_RS22815 Protein ID WP_001309181.1
Coordinates 4610098..4610643 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ24_RS22795 4605789..4607102 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
HQ24_RS22800 4607114..4607392 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
HQ24_RS22805 4607389..4608510 - 1122 WP_000010829.1 M42 family metallopeptidase -
HQ24_RS26670 4608755..4608871 - 117 Protein_4310 VOC family protein -
HQ24_RS25955 4608909..4609127 - 219 Protein_4311 hypothetical protein -
HQ24_RS22810 4609296..4610042 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
HQ24_RS22815 4610098..4610643 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
HQ24_RS22820 4610655..4610912 - 258 WP_001054376.1 hypothetical protein Toxin
HQ24_RS26435 4611289..4611534 - 246 Protein_4315 GNAT family N-acetyltransferase -
HQ24_RS22835 4611650..4612890 + 1241 Protein_4316 helicase YjhR -
HQ24_RS22840 4613473..4614453 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
HQ24_RS22845 4614518..4615624 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4610098..4621888 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T47531 WP_001054376.1 NZ_CP008801:c4610912-4610655 [Escherichia coli KLY]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T47531 NZ_CP008801:c4610912-4610655 [Escherichia coli KLY]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT47531 WP_001309181.1 NZ_CP008801:c4610643-4610098 [Escherichia coli KLY]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT47531 NZ_CP008801:c4610643-4610098 [Escherichia coli KLY]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References