150946

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3598122..3598936 Replicon chromosome
Accession NZ_CP049197
Organism Escherichia coli strain E597

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag G6Z98_RS17030 Protein ID WP_001054376.1
Coordinates 3598122..3598379 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag G6Z98_RS17035 Protein ID WP_001309181.1
Coordinates 3598391..3598936 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z98_RS17010 3593410..3594516 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
G6Z98_RS17015 3594581..3595561 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
G6Z98_RS17020 3596144..3597384 - 1241 Protein_3326 DNA helicase -
G6Z98_RS17025 3597500..3597745 + 246 Protein_3327 GNAT family N-acetyltransferase -
G6Z98_RS17030 3598122..3598379 + 258 WP_001054376.1 hypothetical protein Toxin
G6Z98_RS17035 3598391..3598936 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
G6Z98_RS17040 3598992..3599738 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
G6Z98_RS17045 3599907..3600125 + 219 Protein_3331 hypothetical protein -
G6Z98_RS24540 3600163..3600279 + 117 Protein_3332 VOC family protein -
G6Z98_RS17050 3600524..3601645 + 1122 WP_000010829.1 M42 family metallopeptidase -
G6Z98_RS17055 3601642..3601920 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
G6Z98_RS17060 3601932..3603245 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 3587909..3598936 11027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T150946 WP_001054376.1 NZ_CP049197:3598122-3598379 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T150946 NZ_CP065152:c2147348-2147007 [Escherichia coli O150:H6]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT150946 WP_001309181.1 NZ_CP049197:3598391-3598936 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT150946 NZ_CP065152:2147343-2147419 [Escherichia coli O150:H6]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References