Detailed information of TA system TA090302

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 5077482..5078296
• Replicon: chromosome
• Accession: NZ_CP025401
• Organism: Escherichia coli strain MS8345

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: MS8345_RS26590
• Protein ID: WP_001054376.1
• Coordinates: 5078039..5078296 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A8E0IVE5
• Locus tag: MS8345_RS26585
• Protein ID: WP_001350781.1
• Coordinates: 5077482..5078027 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS8345_RS26560	5073173..5074486	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
MS8345_RS26565	5074498..5074776	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
MS8345_RS26570	5074773..5075894	-	1122	WP_000010829.1	M42 family metallopeptidase	-
MS8345_RS30155	5076139..5076255	-	117	Protein_4872	VOC family protein	-
MS8345_RS26575	5076293..5076511	-	219	Protein_4873	hypothetical protein	-
MS8345_RS26580	5076680..5077426	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
MS8345_RS26585	5077482..5078027	-	546	WP_001350781.1	N-acetyltransferase	Antitoxin
MS8345_RS26590	5078039..5078296	-	258	WP_001054376.1	hypothetical protein	Toxin
MS8345_RS26600	5078673..5078918	-	246	Protein_4877	GNAT family N-acetyltransferase	-
MS8345_RS26610	5079034..5080274	+	1241	Protein_4878	helicase YjhR	-
MS8345_RS26615	5080857..5081837	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
MS8345_RS26620	5081902..5083008	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View HG738867 Escherichia coli str. K-12 substr. MC4100 Genomic island TA020089 4419085..4430625 0.005 View NC_000913 Escherichia coli str. K-12 substr. MG1655 Genomic island TA006279 4533239..4545029 0.001 View NC_007779 Escherichia coli str. K-12 substr. W3110 Genomic island TA021460 4537919..4549709 0.001 View NC_012759 Escherichia coli BW2952 Genomic island TA023876 4469997..4481537 0.005 View NC_017638 Escherichia coli DH1 Genomic island TA027426 4513009..4524807 0.001 View NZ_CP009273 Escherichia coli BW25113 Genomic island TA048705 4523056..4534846 0.001 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Genomic island TA068445 4432698..4444488 0.001 View NZ_HG738867 Escherichia coli str. K-12 substr. MC4100 strain K-12 Genomic island TA285034 4419085..4430625 0.005	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	5077482..5089273	11791

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T90302 WP_001054376.1 NZ_CP025401:c5078296-5078039 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T90302 NZ_CP025401:c5078296-5078039 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19974.91 Da
• Isoelectric Point: 6.3277

>AT90302 WP_001350781.1 NZ_CP025401:c5078027-5077482 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT90302 NZ_CP025401:c5078027-5077482 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCTTTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82