267959

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 574507..575321 Replicon chromosome
Accession NZ_CP116103
Organism Escherichia coli strain DETEC-P836

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag PIB67_RS02765 Protein ID WP_001054376.1
Coordinates 575064..575321 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag PIB67_RS02760 Protein ID WP_001540600.1
Coordinates 574507..575052 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB67_RS02730 (570198) 570198..571511 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
PIB67_RS02735 (571523) 571523..571801 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
PIB67_RS02740 (571798) 571798..572919 - 1122 WP_000010829.1 M42 family metallopeptidase -
PIB67_RS02745 (573164) 573164..573280 - 117 Protein_531 VOC family protein -
PIB67_RS02750 (573318) 573318..573536 - 219 Protein_532 hypothetical protein -
PIB67_RS02755 (573705) 573705..574451 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
PIB67_RS02760 (574507) 574507..575052 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
PIB67_RS02765 (575064) 575064..575321 - 258 WP_001054376.1 YjhX family toxin Toxin
PIB67_RS02770 (575812) 575812..575943 - 132 WP_001309182.1 hypothetical protein -
PIB67_RS02775 (576059) 576059..577299 + 1241 Protein_537 helicase YjhR -
PIB67_RS02780 (577567) 577567..577772 - 206 Protein_538 HNH endonuclease -
PIB67_RS02785 (577882) 577882..578862 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
PIB67_RS02790 (578927) 578927..580033 - 1107 WP_001774143.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 574507..586297 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T267959 WP_001054376.1 NZ_CP116103:c575321-575064 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT267959 WP_001540600.1 NZ_CP116103:c575052-574507 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References