187037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 1100073..1100887 Replicon chromosome
Accession NZ_CP068281
Organism Escherichia coli strain CY706

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JJW04_RS05250 Protein ID WP_001054376.1
Coordinates 1100630..1100887 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JJW04_RS05245 Protein ID WP_001309181.1
Coordinates 1100073..1100618 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJW04_RS05215 (1095764) 1095764..1097077 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
JJW04_RS05220 (1097089) 1097089..1097367 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
JJW04_RS05225 (1097364) 1097364..1098485 - 1122 WP_000010829.1 M42 family metallopeptidase -
JJW04_RS05230 (1098730) 1098730..1098846 - 117 Protein_1012 VOC family protein -
JJW04_RS05235 (1098884) 1098884..1099102 - 219 Protein_1013 hypothetical protein -
JJW04_RS05240 (1099271) 1099271..1100017 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JJW04_RS05245 (1100073) 1100073..1100618 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
JJW04_RS05250 (1100630) 1100630..1100887 - 258 WP_001054376.1 YjhX family toxin Toxin
JJW04_RS23165 (1101378) 1101378..1101509 - 132 WP_001309182.1 hypothetical protein -
JJW04_RS05260 (1101625) 1101625..1102865 + 1241 Protein_1018 helicase YjhR -
JJW04_RS23170 (1103133) 1103133..1103338 - 206 Protein_1019 HNH endonuclease -
JJW04_RS05265 (1103448) 1103448..1104428 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JJW04_RS05270 (1104493) 1104493..1105599 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 1100073..1111862 11789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T187037 WP_001054376.1 NZ_CP068281:c1100887-1100630 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T187037 NZ_CP089776:c3101356-3101000 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT187037 WP_001309181.1 NZ_CP068281:c1100618-1100073 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT187037 NZ_CP089776:c3101570-3101340 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References