181578

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4523062..4523876 Replicon chromosome
Accession NZ_CP064681
Organism Escherichia coli K-12 strain BZKR3G40

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag IVL00_RS21800 Protein ID WP_001054376.1
Coordinates 4523619..4523876 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag IVL00_RS21795 Protein ID WP_001309181.1
Coordinates 4523062..4523607 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVL00_RS21765 4518753..4520066 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
IVL00_RS21770 4520078..4520356 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
IVL00_RS21775 4520353..4521474 - 1122 WP_000010829.1 M42 family metallopeptidase -
IVL00_RS21780 4521719..4521835 - 117 Protein_4237 VOC family protein -
IVL00_RS21785 4521873..4522091 - 219 Protein_4238 hypothetical protein -
IVL00_RS21790 4522260..4523006 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
IVL00_RS21795 4523062..4523607 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
IVL00_RS21800 4523619..4523876 - 258 WP_001054376.1 hypothetical protein Toxin
IVL00_RS21805 4524253..4524498 - 246 Protein_4242 GNAT family N-acetyltransferase -
IVL00_RS21810 4524614..4525854 + 1241 Protein_4243 DNA helicase -
IVL00_RS21815 4526437..4527417 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
IVL00_RS21820 4527482..4528588 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4523062..4534853 11791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T181578 WP_001054376.1 NZ_CP064681:c4523876-4523619 [Escherichia coli K-12]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T181578 NZ_CP085972:882006-882431 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT181578 WP_001309181.1 NZ_CP064681:c4523607-4523062 [Escherichia coli K-12]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT181578 NZ_CP085972:881770-882009 [Bordetella parapertussis]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References