253591

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4410629..4411443 Replicon chromosome
Accession NZ_CP102380
Organism Escherichia coli strain BM28

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NR349_RS21385 Protein ID WP_001054376.1
Coordinates 4411186..4411443 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NR349_RS21380 Protein ID WP_001309181.1
Coordinates 4410629..4411174 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR349_RS21350 (4406320) 4406320..4407633 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
NR349_RS21355 (4407645) 4407645..4407923 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NR349_RS21360 (4407920) 4407920..4409041 - 1122 WP_000010829.1 M42 family metallopeptidase -
NR349_RS21365 (4409286) 4409286..4409402 - 117 Protein_4154 VOC family protein -
NR349_RS21370 (4409440) 4409440..4409658 - 219 Protein_4155 hypothetical protein -
NR349_RS21375 (4409827) 4409827..4410573 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NR349_RS21380 (4410629) 4410629..4411174 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
NR349_RS21385 (4411186) 4411186..4411443 - 258 WP_001054376.1 YjhX family toxin Toxin
NR349_RS21390 (4411934) 4411934..4412065 - 132 WP_001309182.1 hypothetical protein -
NR349_RS21395 (4412181) 4412181..4413421 + 1241 Protein_4160 helicase YjhR -
NR349_RS21400 (4413689) 4413689..4413894 - 206 Protein_4161 HNH endonuclease -
NR349_RS21405 (4414004) 4414004..4414984 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NR349_RS21410 (4415049) 4415049..4416155 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4410629..4423758 13129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T253591 WP_001054376.1 NZ_CP102380:c4411443-4411186 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT253591 WP_001309181.1 NZ_CP102380:c4411174-4410629 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References