60549

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4438440..4439254 Replicon chromosome
Accession NZ_CP014270
Organism Escherichia coli K-12 strain K-12 DHB4

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag DHB4_RS22005 Protein ID WP_001054376.1
Coordinates 4438997..4439254 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag DHB4_RS22000 Protein ID WP_001309181.1
Coordinates 4438440..4438985 (-) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DHB4_RS21980 4434131..4435444 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
DHB4_RS21985 4435456..4435734 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
DHB4_RS21990 4435731..4436852 - 1122 WP_000010829.1 M42 family metallopeptidase -
DHB4_RS27070 4437097..4437213 - 117 Protein_4178 VOC family protein -
DHB4_RS26245 4437251..4437469 - 219 Protein_4179 hypothetical protein -
DHB4_RS21995 4437638..4438384 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
DHB4_RS22000 4438440..4438985 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
DHB4_RS22005 4438997..4439254 - 258 WP_001054376.1 hypothetical protein Toxin
DHB4_RS26775 4439631..4439876 - 246 Protein_4183 GNAT family N-acetyltransferase -
DHB4_RS22020 4439992..4441232 + 1241 Protein_4184 helicase YjhR -
DHB4_RS22025 4441815..4442795 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
DHB4_RS22030 4442860..4443966 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4438440..4450230 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T60549 WP_001054376.1 NZ_CP014270:c4439254-4438997 [Escherichia coli K-12]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T60549 NZ_CP014270:c4439254-4438997 [Escherichia coli K-12]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT60549 WP_001309181.1 NZ_CP014270:c4438985-4438440 [Escherichia coli K-12]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT60549 NZ_CP014270:c4438985-4438440 [Escherichia coli K-12]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References