211118

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4332534..4333348 Replicon chromosome
Accession NZ_CP080155
Organism Escherichia coli strain PK8261

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KZY07_RS20795 Protein ID WP_001054376.1
Coordinates 4332534..4332791 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag KZY07_RS20800 Protein ID WP_001309181.1
Coordinates 4332803..4333348 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY07_RS20775 (4327822) 4327822..4328928 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
KZY07_RS20780 (4328993) 4328993..4329973 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KZY07_RS27715 (4330083) 4330083..4330288 + 206 Protein_4091 HNH endonuclease -
KZY07_RS20785 (4330556) 4330556..4331796 - 1241 Protein_4092 helicase YjhR -
KZY07_RS27720 (4331912) 4331912..4332043 + 132 WP_001309182.1 hypothetical protein -
KZY07_RS20795 (4332534) 4332534..4332791 + 258 WP_001054376.1 YjhX family toxin Toxin
KZY07_RS20800 (4332803) 4332803..4333348 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
KZY07_RS20805 (4333404) 4333404..4334150 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KZY07_RS20810 (4334319) 4334319..4334537 + 219 Protein_4097 hypothetical protein -
KZY07_RS20815 (4334575) 4334575..4334691 + 117 Protein_4098 VOC family protein -
KZY07_RS20820 (4334936) 4334936..4336057 + 1122 WP_000010829.1 M42 family metallopeptidase -
KZY07_RS20825 (4336054) 4336054..4336332 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KZY07_RS20830 (4336344) 4336344..4337657 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimI / fimA / fimE / fimB 4322320..4333348 11028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T211118 WP_001054376.1 NZ_CP080155:4332534-4332791 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T211118 NZ_CP104698:3715731-3716114 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT211118 WP_001309181.1 NZ_CP080155:4332803-4333348 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT211118 NZ_CP104698:3715513-3715734 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATCTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References