Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2863259..2864073 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QCG48_RS14310 Protein ID WP_001054376.1
Coordinates 2863816..2864073 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QCG48_RS14305 Protein ID WP_001309181.1
Coordinates 2863259..2863804 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS14275 (2858950) 2858950..2860263 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
QCG48_RS14280 (2860275) 2860275..2860553 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QCG48_RS14285 (2860550) 2860550..2861671 - 1122 WP_000010829.1 M42 family metallopeptidase -
QCG48_RS14290 (2861916) 2861916..2862032 - 117 Protein_2785 VOC family protein -
QCG48_RS14295 (2862070) 2862070..2862288 - 219 Protein_2786 hypothetical protein -
QCG48_RS14300 (2862457) 2862457..2863203 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QCG48_RS14305 (2863259) 2863259..2863804 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
QCG48_RS14310 (2863816) 2863816..2864073 - 258 WP_001054376.1 YjhX family toxin Toxin
QCG48_RS14315 (2864564) 2864564..2864695 - 132 WP_001309182.1 hypothetical protein -
QCG48_RS14320 (2864811) 2864811..2866051 + 1241 Protein_2791 helicase YjhR -
QCG48_RS14325 (2866319) 2866319..2866524 - 206 Protein_2792 HNH endonuclease -
QCG48_RS14330 (2866634) 2866634..2867614 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QCG48_RS14335 (2867679) 2867679..2868785 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 2863259..2875049 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T276675 WP_001054376.1 NZ_CP122316:c2864073-2863816 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT276675 WP_001309181.1 NZ_CP122316:c2863804-2863259 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References