Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4448254..4449068 Replicon chromosome
Accession NZ_CP077969
Organism Escherichia coli strain JM83

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KTJ86_RS21495 Protein ID WP_001054376.1
Coordinates 4448811..4449068 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag KTJ86_RS21490 Protein ID WP_001309181.1
Coordinates 4448254..4448799 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ86_RS21460 (4443945) 4443945..4445258 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
KTJ86_RS21465 (4445270) 4445270..4445548 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KTJ86_RS21470 (4445545) 4445545..4446666 - 1122 WP_000010829.1 M42 family metallopeptidase -
KTJ86_RS21475 (4446911) 4446911..4447027 - 117 Protein_4187 VOC family protein -
KTJ86_RS21480 (4447065) 4447065..4447283 - 219 Protein_4188 hypothetical protein -
KTJ86_RS21485 (4447452) 4447452..4448198 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KTJ86_RS21490 (4448254) 4448254..4448799 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
KTJ86_RS21495 (4448811) 4448811..4449068 - 258 WP_001054376.1 YjhX family toxin Toxin
KTJ86_RS22100 (4449559) 4449559..4449690 - 132 WP_001309182.1 hypothetical protein -
KTJ86_RS21505 (4449806) 4449806..4451046 + 1241 Protein_4193 helicase YjhR -
KTJ86_RS22105 (4451314) 4451314..4451519 - 206 Protein_4194 HNH endonuclease -
KTJ86_RS21510 (4451629) 4451629..4452609 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KTJ86_RS21515 (4452674) 4452674..4453780 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4448254..4460044 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T208777 WP_001054376.1 NZ_CP077969:c4449068-4448811 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T208777 NZ_CP103729:327692-328060 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT208777 WP_001309181.1 NZ_CP077969:c4448799-4448254 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT208777 NZ_CP103729:327474-327695 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References