285673

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4529713..4530527 Replicon chromosome
Accession NZ_LN832404
Organism Escherichia coli K-12 substr. AG100

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EK12AG100_RS22415 Protein ID WP_001054376.1
Coordinates 4530270..4530527 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag EK12AG100_RS22410 Protein ID WP_001309181.1
Coordinates 4529713..4530258 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK12AG100_RS22390 4525404..4526717 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
EK12AG100_RS22395 4526729..4527007 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EK12AG100_RS22400 4527004..4528125 - 1122 WP_000010829.1 M42 family metallopeptidase -
EK12AG100_RS26025 4528370..4528486 - 117 Protein_4239 VOC family protein -
EK12AG100_RS25395 4528524..4528742 - 219 Protein_4240 hypothetical protein -
EK12AG100_RS22405 4528911..4529657 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EK12AG100_RS22410 4529713..4530258 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
EK12AG100_RS22415 4530270..4530527 - 258 WP_001054376.1 hypothetical protein Toxin
EK12AG100_RS25870 4530904..4531149 - 246 Protein_4244 GNAT family N-acetyltransferase -
EK12AG100_RS22430 4531265..4532505 + 1241 Protein_4245 helicase YjhR -
EK12AG100_RS22435 4533088..4534068 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EK12AG100_RS22440 4534133..4535239 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4529713..4541503 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T285673 WP_001054376.1 NZ_LN832404:c4530527-4530270 [Escherichia coli K-12]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT285673 WP_001309181.1 NZ_LN832404:c4530258-4529713 [Escherichia coli K-12]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References