160068

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4585030..4585844 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag HUR94_RS22425 Protein ID WP_001054376.1
Coordinates 4585587..4585844 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag HUR94_RS22420 Protein ID WP_001309181.1
Coordinates 4585030..4585575 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS22390 (4580721) 4580721..4582034 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
HUR94_RS22395 (4582046) 4582046..4582324 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
HUR94_RS22400 (4582321) 4582321..4583442 - 1122 WP_000010829.1 M42 family metallopeptidase -
HUR94_RS22405 (4583687) 4583687..4583803 - 117 Protein_4358 VOC family protein -
HUR94_RS22410 (4583841) 4583841..4584059 - 219 Protein_4359 hypothetical protein -
HUR94_RS22415 (4584228) 4584228..4584974 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
HUR94_RS22420 (4585030) 4585030..4585575 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
HUR94_RS22425 (4585587) 4585587..4585844 - 258 WP_001054376.1 YjhX family toxin Toxin
HUR94_RS22430 (4586335) 4586335..4586466 - 132 WP_001309182.1 hypothetical protein -
HUR94_RS22435 (4586582) 4586582..4587822 + 1241 Protein_4364 helicase YjhR -
HUR94_RS22440 (4588090) 4588090..4588295 - 206 Protein_4365 HNH endonuclease -
HUR94_RS22445 (4588405) 4588405..4589385 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
HUR94_RS22450 (4589450) 4589450..4590556 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimB / fimE / fimA / fimI / fimC 4585030..4596820 11790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T160068 WP_001054376.1 NZ_CP054665:c4585844-4585587 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T160068 NZ_CP070287:c4566080-4565706 [Escherichia albertii]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATTGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCACT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGTTGGCGCTAAAAAATACAATCAAG
AACATCGCACACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATCGCGGAACGAAGCGTTGCTTTG
AGACAAGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAATTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTAATCACACCCTATCAATCGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT160068 WP_001309181.1 NZ_CP054665:c4585575-4585030 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT160068 NZ_CP070287:c4566322-4566080 [Escherichia albertii]
ATGAGCGCTATGGCAGGTATGGATATGGGCAGAATTTTACTCGATTTATCCGATGAGGTGATTAAGCGACTTGATGATCT
CAAAGTGCAGCGCAATCTTCCTCGCGCAGAGCTATTACGAGAAGCGGTAGATCAATATCTGGAAAATCAATCGAAAACGA
CAATATCCAGTGCTCTTGGTATCTGGCAAGGGTGTGAGGAAGATGGTGTCGAATATCAGCGTAAGCTGCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References